People who have higher blood glucose levels and poorer control of those levels are more likely to develop eye-related complications 10 years later, according to a study.
Pascale Massin, of Hopital Lariboisiere, Paris, and colleagues in the Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study Group examined the retinas of 700 men and women (average age 52) who were enrolled in the study.
Over the preceding nine years, their fasting plasma glucose levels and hemoglobin A1C (HbA1c, a measure of blood glucose control over time) had been tracked. In that time, 235 had diabetes (defined as being treated for the disease or having a glucose level of 126 milligrams per deciliter or higher at least once), 227 had an impaired fasting plasma glucose level (110 to 125 milligrams per deciliter) and 238 always had glucose levels within normal limits (less than 110 milligrams per deciliter).
"Levels of HbA1c and fasting plasma glucose at baseline were related to the presence of retinopathy 10 years later, and the levels at which the positive predictive values increased provide a rationale for the choice of thresholds for the definition of hyperglycemia associated with 10-year retinopathy," the authors wrote.
The study has been published in the Archives of Ophthalmology.