About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Blocking Enzyme can Reduce Brain Damage Shortly After a Stroke

by Bidita Debnath on June 30, 2014 at 7:33 PM
Font : A-A+

 Blocking Enzyme can Reduce Brain Damage Shortly After a Stroke

Inhibiting Cdk5 enzyme could help minimize brain damage if administered shortly after a stroke, reveals a new research.

Dr. James Bibb, Associate Professor of Neurology and Neurotherapeutics at UT Southwestern said that if people inhibit Cdk5, then the vast majority of brain tissue stays alive without oxygen for up to one hour, which tells them that Cdk5 is a central player in nerve cell death.

Advertisement

He further explained that they are not yet at a point where this new treatment can be given for stroke but this research brings them a step closer to developing the right kinds of drugs.

While several pharmaceutical companies worked to develop Cdk5 inhibitors years ago, these efforts were largely abandoned since research indicated blocking Cdk5 long-term could have detrimental effects.
Advertisement

However the latest study indicated that Cdk5 has both good and bad effects like when working normally, it added phosphates to other proteins that are important to healthy brain function but researchers also found that aberrant Cdk5 activity contributeed to nerve cell death following brain injury and could lead to cancer.

Currently, there is only one FDA-approved drug for acute treatment of stroke, the clot-busting drug tPA and other treatment options include neurosurgical procedures to help minimize brain damage.

The researchers established that no Cdk5 blocker exists that works in a pill form, so the next step would be to develop a systemic drug that could be used to confirm the study's results.

The research is published in the Journal of Neuroscience.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Health Benefits of Sea Buckthorn
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Coma Parkinsons Disease Parkinsons Disease Surgical Treatment Bell´s Palsy Diet Lifestyle and Heart Disease Mitral Valve Stenosis And Mitral Valve Replacement Congenital Heart Disease Stress and the Gender Divide Stroke Facts Stroke 

Recommended Reading
Stroke
Stroke can cause permanent disability and it is important to recognize its early warning signs to .....
New Helmet That can Detect Hemorrhagic Stroke Developed
A group of Swedish researchers has developed a helmet that can quickly detect whether a patient is ....
High CD4 Cell Counts Linked to a Reduced Risk of Ischemic Stroke for Those With HIV
HIV positive individuals have a 40% higher risk of ischemic stroke, however, these stroke rates are ...
Microwave Helmet Strokefinder Differentiates Bleeding Strokes from Clot-Induced Strokes
For rapid and accurate diagnosis of stroke patients, the results from the initial clinical studies ....
Coma
Coma is a deep state of unconsciousness where the affected individual is alive but is not able to re...
Congenital Heart Disease
Heart diseases that are present at birth are called “ Congenital heart diseases”....
Mitral Valve Stenosis And Mitral Valve Replacement
Mitral valve replacement is a surgical heart procedure to correct either the narrowing (stenosis) or...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Stress and the Gender Divide
Stress has become entwined in the current lifestyle of a young working couple and has resulted in th...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use