The existing mouse models of cancer have been compared to human cancer samples by researchers from the Fred Hutchinson Cancer Research Center in Seattle.

Cancer is a multistep process that involves a complex interplay between genetic and epigenetic alterations. Epigenetic modifications mediate changes in gene expression without altering the DNA sequence. One of those modifications, DNA methylation, was found to be significantly different between mouse models of medulloblastoma and primary medulloblastoma human samples.
Source-Eurekalert