Chronic hepatitis B virus (HBV) infection has been successfully treated in woodchucks by US researchers by orally administering them various combined and independent antiviral drug therapies.
The researchers evaluated the antiviral effects of orally administered adefovir dipivoxil (ADV) or tenofovir disoproxil fumarate (TDF) alone, or in combination with lamivudine (3TC) or emtricitabine (FTC) in woodchucks with chronic hepatitis virus infection.
Hepatitis A
Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. Hepatitis A vaccine is available that is 95% effective in preventing the disease.
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They found that once daily treatment for 48 weeks with ADV plus 3TC or TDF plus FTC greatly reduced viral levels from those pre-treatment.
It was further observed that an additional treatment with TDF plus 3TC, ADV alone, ADV plus FTC, TDF alone, 3TC alone, and FTC alone showed pronounced declines in viral levels in all groups.
![Alcoholic Liver Disease]( "Alcoholic Liver Disease")
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While most woodchucks displayed renewed hepatitis virus replication following drug withdrawal, some did experience sustained effects.
The team, including researchers from Cornell University and Georgetown Universtiy Medical Center, did not find any toxicity following administration of any of the drugs or drug combinations.
"In conclusion, the oral administration of 3TC, FTC, ADV, and TDF alone and in combination was safe and effective in the woodchuck model of HBV infection," said the researchers.
An article describing the study has been published in the journal Antimicrobial Agents and Chemotherapy.
Source: ANI
RAS/SK
Alcoholic Liver Disease
Encyclopedia section of medindia gives general information about Alcoholic Liver Disease.
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While most woodchucks displayed renewed hepatitis virus replication following drug withdrawal, some did experience sustained effects.
The team, including researchers from Cornell University and Georgetown Universtiy Medical Center, did not find any toxicity following administration of any of the drugs or drug combinations.
"In conclusion, the oral administration of 3TC, FTC, ADV, and TDF alone and in combination was safe and effective in the woodchuck model of HBV infection," said the researchers.
An article describing the study has been published in the journal Antimicrobial Agents and Chemotherapy.
Source: ANI
RAS/SK
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