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Anthrax Could Aid in Fighting Bladder Cancer: Study

by Ramya Rachamanti on Nov 13 2019 7:12 PM

Anthrax Could Aid in Fighting Bladder Cancer: Study
Anthrax toxin has potential to treat bladder cancer, according to the research published in the International Journal of Cancer.
The current treatments for bladder cancer are invasive for patients - who often must sit for hours at a time with a bladder full of an agent designed to kill cancer cells and tumors. Bladder cancer also is one of the most reoccurring for people diagnosed with the disease.

"We have effectively come up with a promising method to kill the cancer cells without harming the normal cells in the bladder," said R. Claudio Aguilar, an associate professor and the assistant head of biological sciences in Purdue's College of Science. "It is basically like creating a special solution that targets cancer cells while leaving healthy cells alone."

Aguilar said the bladder has its own protective layer, which saves the good cells from the anthrax mixture but offers no protection for the cancer cells and tumors. He said the Purdue system works within minutes - instead of the usual hours for bladder cancer treatment - to target the cancer cells in the bladder.

"We have seen outstanding results with our treatment," said Aguilar, who works as part of a team focused on cell identity and signaling at the Purdue University Center for Cancer Research. "It is fast and effective, both of which are critical for people dealing with this devastating disease."

Aguilar and his group worked with the Purdue teams led by Timothy Ratliff and Deborah Knapp to test their solution in dogs with bladder cancer who had run out of other treatment options. They found this new agent decreased the tumor size without causing any other side effects in the animals.

The Purdue team thinks a similar treatment may help people and animals with other cancers, including those affecting the lungs or skin.

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Source-Eurekalert


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