Bacteria present in the ancient Irish soil can halt the growth of superbugs, finds a new study. The results of this study are published in the journal of Frontiers in Microbiology.
Researchers analyzing soil from Ireland long thought to have medicinal properties have discovered that it contains a previously unknown strain of bacteria which is effective against four of the top six superbugs that are resistant to antibiotics, including MRSA.
Antibiotic Resistance Linked to Frequency of Usage in the U.S.A
Widespread and occasional use of antibiotics plays more role in causing resistance when compared to repeated use by small fraction of the population
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‘"This new strain of bacteria is effective against 4 of the top 6 pathogens that are resistant to antibiotics, including MRSA. Our discovery is an important step forward in the fight against antibiotic resistance, says Paul Dyson, lead author of the study.’
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Antibiotic-resistant superbugs could kill up to 1.3 million people in Europe by 2050, according to recent research.
The World Health Organisation (WHO) describes the problem as "one of the biggest threats to global health, food security, and development today."
![Over 6,000 Antibiotic Resistance Genes in the Bacteria That Inhabit the Human Gut Discovered]( "Over 6,000 Antibiotic Resistance Genes in the Bacteria That Inhabit the Human Gut Discovered")
New method to identify resistance genes in gut bacteria by comparing the three-dimensional structures of known antibiotic resistance enzymes to the proteins that are produced by gut bacteria identified.
The new strain of bacteria was discovered by a team based in Swansea University Medical School, made up of researchers from Wales, Brazil, Iraq and Northern Ireland.
They have named the new strain Streptomyces sp. myrophorea. The soil they analyzed originated from an area of Fermanagh, Northern Ireland, which is known as the Boho Highlands. It is an area of alkaline grassland, and the soil is reputed to have healing properties.
The search for replacement antibiotics to combat multi-resistance has prompted researchers to explore new sources, including folk medicines: a field of study known as ethnopharmacology. They are also focusing on environments where well-known antibiotic producers like Streptomyces can be found.
One of the research team, Dr. Gerry Quinn, a previous resident of Boho, County Fermanagh, had been aware of the healing traditions of the area for many years.
Traditionally a small amount of soil was wrapped up in a cotton cloth and used to heal many ailments including a toothache, throat and neck infections. Interestingly, this area was previously occupied by the Druids, around 1500 years ago, and Neolithic people 4000 years ago.
The main findings of the research were that the newly-identified strain of Streptomyces:
Inhibited the growth of four of the top six multi-resistant pathogens identified by the WHO as being responsible for healthcare-associated infections: Vancomycin-resistant Enterococcus faecium (VRE), methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumonia, and Carbapenem-resistant Acinetobacter baumanii Inhibited both gram positive and gram negative bacteria, which differ in the structure of their cell wall; usually, gram negative bacteria are more resistant to antibiotics
It is not yet clear which component of the new strain prevents the growth of the pathogens, but the team are already investigating this.
Professor Paul Dyson of Swansea University Medical School said:
"This new strain of bacteria is effective against 4 of the top 6 pathogens that are resistant to antibiotics, including MRSA. Our discovery is an important step forward in the fight against antibiotic resistance.
Our results show that folklore and traditional medicines are worth investigating in the search for new antibiotics. Scientists, historians, and archaeologists can all have something to contribute to this task. It seems that part of the answer to this very modern problem might lie in the wisdom of the past."
Dr. Gerry Quinn from the research team said:
"The discovery of antimicrobial substances from Streptomyces sp.myrophorea will help in our search for new drugs to treat multi-resistant bacteria, the cause of many dangerous and lethal infections.
We will now concentrate on the purification and identification of these antibiotics. We have also discovered additional antibacterial organisms from the same soil cure which may cover a broader spectrum of multi-resistant pathogens."
Source: Eurekalert
Over 6,000 Antibiotic Resistance Genes in the Bacteria That Inhabit the Human Gut Discovered
New method to identify resistance genes in gut bacteria by comparing the three-dimensional structures of known antibiotic resistance enzymes to the proteins that are produced by gut bacteria identified.
Advertisement
The new strain of bacteria was discovered by a team based in Swansea University Medical School, made up of researchers from Wales, Brazil, Iraq and Northern Ireland.
They have named the new strain Streptomyces sp. myrophorea. The soil they analyzed originated from an area of Fermanagh, Northern Ireland, which is known as the Boho Highlands. It is an area of alkaline grassland, and the soil is reputed to have healing properties.
The search for replacement antibiotics to combat multi-resistance has prompted researchers to explore new sources, including folk medicines: a field of study known as ethnopharmacology. They are also focusing on environments where well-known antibiotic producers like Streptomyces can be found.
One of the research team, Dr. Gerry Quinn, a previous resident of Boho, County Fermanagh, had been aware of the healing traditions of the area for many years.
Traditionally a small amount of soil was wrapped up in a cotton cloth and used to heal many ailments including a toothache, throat and neck infections. Interestingly, this area was previously occupied by the Druids, around 1500 years ago, and Neolithic people 4000 years ago.
The main findings of the research were that the newly-identified strain of Streptomyces:
Inhibited the growth of four of the top six multi-resistant pathogens identified by the WHO as being responsible for healthcare-associated infections: Vancomycin-resistant Enterococcus faecium (VRE), methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumonia, and Carbapenem-resistant Acinetobacter baumanii Inhibited both gram positive and gram negative bacteria, which differ in the structure of their cell wall; usually, gram negative bacteria are more resistant to antibiotics
It is not yet clear which component of the new strain prevents the growth of the pathogens, but the team are already investigating this.
Professor Paul Dyson of Swansea University Medical School said:
"This new strain of bacteria is effective against 4 of the top 6 pathogens that are resistant to antibiotics, including MRSA. Our discovery is an important step forward in the fight against antibiotic resistance.
Our results show that folklore and traditional medicines are worth investigating in the search for new antibiotics. Scientists, historians, and archaeologists can all have something to contribute to this task. It seems that part of the answer to this very modern problem might lie in the wisdom of the past."
Dr. Gerry Quinn from the research team said:
"The discovery of antimicrobial substances from Streptomyces sp.myrophorea will help in our search for new drugs to treat multi-resistant bacteria, the cause of many dangerous and lethal infections.
We will now concentrate on the purification and identification of these antibiotics. We have also discovered additional antibacterial organisms from the same soil cure which may cover a broader spectrum of multi-resistant pathogens."
Source: Eurekalert
Antibiotic Resistance: Less in Places Where Clean Water, & Sanitation are Present
Direct link between country's public health infrastructure spending and antibiotic resistance has been found in this study.
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