About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

An Explanation for Crohn's Disease - Maybe

by Rajashri on July 11, 2009 at 9:23 PM
Font : A-A+

 An Explanation for Crohn's Disease - Maybe

A mutation in the NOD2 gene is present in 25% of patients with Crohn's disease, but it is not precisely known how this mutation influences the disease.

The latest study by Dr. Marcel Behr, of the Research Institute of the MUHC and McGill University, has provided new insight into how this might occur. The study will be published on July 9th in the Journal of Experimental Medicine.

Advertisement

When the NOD2 gene functions normally, it codes for a receptor that will recognize invading bacteria and then trigger the immune response. This study demonstrates that the NOD2 receptor preferentially recognizes a peptide called N-glycolyl-MDP, which is only found in a specific family of bacteria called mycobacteria. When mycobacteria invade the human body, they cause an immediate and very strong immune response via the NOD2 receptor.

"Now that we have a better understanding of the normal role of NOD2, we think that a mutation in this gene prevents mycobacteria from being properly recognized by the immune system," explained Dr. Behr. "If mycobacteria are not recognized, the body cannot effectively fight them off and then becomes persistently infected."
Advertisement

Researchers were already aware of the relationship between mycobacteria and Crohn's disease, but they did not know whether the presence of bacteria was a cause or a consequence of the disease. This new discovery associates the predisposition for Crohn's disease with both the NOD2 mutation and the presence of mycobacteria, but researchers must still determine the precise combination of these factors to understand how the disease develops.

More research is required to establish a complete explanation. From this, it is expected that new therapeutic approaches that fight the cause of Crohn's disease may be developed



Source: Eurekalert
RAS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge on Lung Transplantation
Baldness can be Cured and Prevented: let us see How!
Drinking Beer or Wine Every Day Could Cause Age-related Diseases
View all
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

Most Popular on Medindia

Noscaphene (Noscapine) Vent Forte (Theophylline) Pregnancy Confirmation Calculator Accident and Trauma Care Loram (2 mg) (Lorazepam) Drug - Food Interactions Blood - Sugar Chart Sanatogen Drug Side Effects Calculator Indian Medical Journals
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use