Ambulance nitroglycerin patch to lower blood pressure did not improve stroke outcomes, says study. The study has been presented at the American Stroke Association's International Stroke Conference 2019, a world premier meeting for researchers and clinicians dedicated to the science and treatment of cerebrovascular disease.
In a multicenter prospective randomized single-masked, blinded-endpoint trial called Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2), United Kingdom researchers investigated whether it is safe and effective for paramedics to administer nitroglycerin.
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‘ransdermal (skin patch) delivery of nitroglycerin (also called glyceryl trinitrate), a nitric oxide donor that lowers blood pressure, might improve functional outcome and reduce death if given very soon after clot-caused stroke (ischemic stroke) or bleeding in the brain (intracerebral hemorrhage).’
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The study included 1,149 patients (average age 73, 52 percent male) with presumed stroke and systolic blood pressure above 120 mm Hg. They were randomized to receive either a nitroglycerin patch or a sham patch within four hours of symptom onset. More than half (57percent) had been diagnosed with high blood pressure, 24 percent had a previous stroke, while 20 percent had diabetes or atrial fibrillation. The primary outcome was a shift in disability measured at three months.
"However, nitroglycerin did not improve overall outcome," said Philip Bath, D.Sc., Stroke Association Professor of Stroke Medicine at University of Nottingham, Nottingham, United Kingdom. "In patients with a brain bleed, the patch appeared to worsen outcomes. So, treatment with nitroglycerin cannot be recommended very early after stroke."
The study was funded by the British Heart Foundation.
Source: Eurekalert
The study was funded by the British Heart Foundation.
Source: Eurekalert
Stroke
Stroke can cause permanent disability and it is important to recognize its early warning signs to stop its progress. Early warning signs of stroke include sudden weakness of facial muscles.
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 Quiz on StrokeStroke is the third leading cause of death world over. Besides, it also disables the affected people, making them completely dependent on caregivers for their daily needs. Lifestyle greatly affects the chances of developing a stroke. Thus, the incidence of stroke can be brought down to a great extent by leading a healthy lifestyle. Here is a quiz that tests if you know enough about this disabling | Advertisement
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Stroke Risk Calculator
Stroke Risk Calculator checks if you have hypertension, diabetes and heart failure and predicts the risk of stroke (cerebrovascular accident) in next 10 years.
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