Ambulance nitroglycerin patch to lower blood pressure did not improve stroke outcomes, says study. The study has been presented at the American Stroke Association's International Stroke Conference 2019, a world premier meeting for researchers and clinicians dedicated to the science and treatment of cerebrovascular disease.
In a multicenter prospective randomized single-masked, blinded-endpoint trial called Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2), United Kingdom researchers investigated whether it is safe and effective for paramedics to administer nitroglycerin.
The study included 1,149 patients (average age 73, 52 percent male) with presumed stroke and systolic blood pressure above 120 mm Hg. They were randomized to receive either a nitroglycerin patch or a sham patch within four hours of symptom onset. More than half (57percent) had been diagnosed with high blood pressure, 24 percent had a previous stroke, while 20 percent had diabetes or atrial fibrillation. The primary outcome was a shift in disability measured at three months.
The study was funded by the British Heart Foundation.