by Karishma Abhishek on  December 30, 2020 at 8:57 AM Clinical Trials News
Aerobic Exercise Can Improve Cognition After Spinal Cord Injury
Impaired cerebrovascular responses to memory tasks in individuals with SCI can be improved by aerobic exercise training, as per a study published in the journal Medicine & Science in Sports & Exercise, American College of Sports Medicine.

Despite existing evidences on the increased incidence of cognitive impairment after spinal cord injury, the exact physiology that underlies this post injury cognitive decline remains unclear.

One of the probable paths includes impaired neurovascular coupling -ability of cerebral vasculature to alter regional blood flow to sustain neural metabolism /activity.


Neurovascular coupling in SCI:

To address the mechanism in the spinal cord injury, the research team analyzed the effect of injury and 6-month full-body aerobic exercise training on the cerebral blood flow response to cognitive demand (i.e., neurovascular coupling) in 24 individuals with SCI and 16 controls.

Cognitive demand was introduced in a graded fashion using a working memory task. Individuals with SCI (especially higher level injuries >T4) showed a longer reaction time most likely due to upper motor impairments.

T4 is the thoracic level of spinal cord that predominantly supplies nerves to upper part of the body. Individuals with low-level injuries (below T4) had higher aerobic capacity than high-level injuries and with training, the capacity increased in both groups.

It was observed that there was no overall significant improvement in neurovascular coupling with training at the group level. However improvement correlation between the neurovascular coupling and aerobic exercise was found in individuals with high-level injuries with increased reaction time but not low-level injuries.

Thus the study states that "the cognitive impairment after SCI reflects a decline in neurovascular coupling primarily due to physical deconditioning rather than injury itself. The latter can be mitigated by aerobic exercise training".

Source: Medindia

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