The University of Utah study is in the Journal of Cell Biology.
Humans have four genes responsible for the production of beta spectrin protein.
Recent studies have shown that people with a condition called spinocerebellar ataxia type 5, a neurodegenerative disease that develops between the ages of 10 and 68, have a mutation in one of the genes.
It was previously thought that the mutation in this protein meant cells could not communicate properly because the necessary proteins would not be anchored in place.
But research by Professor Michael Bastiani and colleagues at the University of Utah suggests that a mutation in or absence of the protein causes long nerve fibres (axons) to lose their flexibility and break.
When nematode worms were bred without beta spectrin their nerve axons died over time and caused paralysis.
In worm embryos only 3% of nerve cells were broken or defective but that grew to 60% by the time the worms were a day old, suggesting the protein is not responsible for initial growth of nerve cells but for preventing breakage later on.
Professor Bastiani said the team found it "incredible" that the one protein was responsible for preventing nerves breaking in your whole body.
"The entire functioning of the nervous system depends on these wire-like axons between nerve cells," he said.
He added that when the worms were paralysed by a second mutation the nerve axons did not break because the worms were not moving around.
"What was surprising was in the past, it's always been embedded in the literature that the thing that provides the strength and flexibility was the neurofilaments.
"We're proposing a completely different model."
There are thought to be more than 20 types of hereditary spinocerebellar ataxia, for which there is no treatment and commonly results in people needing a wheelchair.
The gene for spinocerebellar ataxia type 5 has been discovered in 11 generations of US President Abraham Lincoln's family and it is thought it may have afflicted Lincoln himself although it did not become apparent before he was assassinated at the age of 56.
Professor Patrick Chinnery, professor of neurogenetics at the University of Newcastle, said that hereditary spinocerebellar ataxia was probably more common than once thought and could affect up to 10,000 people in the UK.
"It seems that inherited ataxias that are dominant are due to gene repeats that that leads to an extra long string on the protein causing cell damage."
"This is a completely different mechanism."