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Drug information on Avcef-TZ (1125 mg) (Ceftriaxone) from Arvincare Healthcare

Avcef-TZ (1125 mg)

Arvincare Healthcare
Generic : Ceftriaxone
1 Vial
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Drug Name : Ceftriaxone

Ceftriaxone(Rocephin) generic Ceftriaxone is indicated for: • Lower Respiratory Tract Infections • Skin infections • Urinary Tract Infections • Pelvic Inflammatory Disease –infections related to the female genital tract Bacterial Septicemia-infection in the blood • Bone and Joint Infections • Meningitis • Surgical Prophylaxis –To prevent infections during surgery.
More Info about Ceftriaxone

Dhanalakshmi Chinnuswamy
Further Checked by The Medindia Medical Review Team on February, 2, 2017

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Medical Condition(s) for which Avcef-TZ (1125 mg) may be prescribed

Overview of Avcef-TZ (1125 mg)

Ceftriaxone is an antibiotic, used for the treatment of various infections.

Side effects of Avcef-TZ (1125 mg)

  Central Nervous System: Dizziness, Headache.

  Gastrointestinal: Diarrhea, nausea and vomiting.

  Blood: High concentration of eosinophils, platelet counts in the blood, decrease in white blood cells, low prothrombin levels, bleeding.

  Lab tests: Increase in liver enzyme, elevated BUN (Blood urea, nitrogen).

  Local: Indurations/tightness/warmth.

  Genitourinary: Vaginal inflammation.

  Miscellaneous: Fatal ceftriaxone-calcium precipitates in lung and kidneys of neonates.

Dosage & When it is to be taken (Indications)

Middle ear infection: Children - IM A single dose of 50 mg/kg (max, 1 gram) is recommended.
Meningitis in children: Children - IV: Recommended initial dose is 100 mg/kg (max, 4 gram), followed by 100 mg/kg/day (max, 4 gram/day) for 7 to 14 days.
Skin or Skin Structure Infections: Children - IV/IM: Recommended daily dosage is 50 to 75 mg/kg once a day or in equally divided doses twice daily (max, 2 gram/day).
Surgical Prophylaxis: Adults - IV: 1 gram as a single dose 30 min to 2 hours before surgery.
Uncomplicated Gonococcal Infections: Adults - IM: 250 mg as single dose.
Miscellaneous Infections: Adults - IV: Usual adult daily dosage is 1 to 2 g once a day or in equally divided doses twice daily, depending on the type and severity of infection (max, 4 gram/day).
Children- IV: Recommended daily dose is 50 to 75 mg/kg IV once a day or in divided doses every 12 h (max, 2 gram/day). IV/IM: Recommended daily dose is 50 to 75 mg/kg IV/IM in divided doses every 12 h (max, 2 gram/day).
Acute Bacterial Otitis Media Persistent/Treatment Failure: Children - IM/IV 50 mg/kg/ IM or IV (not to exceed 1 gram) daily for 3 days.
Pelvic Inflammatory Disease (mild to moderate): Adults - IM 250 mg given IM as a single dose with doxycycline 100 mg orally twice daily for 14 days, with or without metronidazole 500 mg orally twice daily for 14 days.
Uncomplicated Gonococcal Infections: Adults - IM 125 mg given IM as a single dose.
Typhoid:Adult- IV: 4gm/day for 2 days, followed by 2g/day. Child- 75mg/day for 2 days.

How to use Avcef-TZ (1125 mg)?

It should be given by intravenous route only over around 30 minutes.
The usual Adult Dose is 1 g to 2 g once a day or in equally divided doses twice a day.
The total dose should not exceed 4 grams.
Patients with liver and kidney problems should not receive more than 2 grams per day of ceftriaxone.

When is Avcef-TZ (1125 mg) not to be taken? (Contraindications)

Ceftriaxone should not be used by patients with allergy to ceftriaxone or other cephalosporin class antibacterials, penicillins, or other beta-lactam antibacterials

Warnings and Precautions for Avcef-TZ (1125 mg)

• Ceftriaxone may cause allergic reactions. Cross-allergies may occur in up to 10% of patients with a history of penicillin allergy. Discontinue the drug in this case.
• The drug may cause Clostridium difficile-associated diarrhea
• Avoid excess dosage

Other Precautions for Avcef-TZ (1125 mg)

Caution is needed in patients with:
• Hemolytic anemia
• Kidney problems
• Liver problems

Drug Interactions of Avcef-TZ (1125 mg)

Do not take Ceftriaxone with:
• Vancomycin
• Amsacrine
• Aminoglycosides
• Fluconazole
• Calcium-containing products

Storage Conditions for Avcef-TZ (1125 mg)

Injection: Store below 25°C. Store it at room temperature and keep away from children.

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For the above reasons Medindia cannot be held liable for any action taken based on the information provided by its website. The purpose of this website is to only provide the initial guidance and it does not intend to replace professional medical opinion in any manner whatsoever.

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