Dalteparin - Drug Information
Generic Name : Dalteparin
Pronunciation : dal te pa' rin
ICD Code : Y44.2 | Therapeutic Classification : Anticoagulants / Antithrombotics
Trade Name(s) :
India - Fragmin 2500IU Injection, Fragmin PF-syringe, Fragmin PF-syringe, Fragmin vial, Fragmin vial, Daltehep, Daltehep (5000 iu)International - Fragmin.
Why is Dalteparin Prescribed? (Indications)
This medication is an anticoagulant (blood thinner) that prevents blood clots in persons undergoing surgery. Along with aspirin this medication is prescribed for heart attack, unstable angina (chest pain). It is also used to reduce the recurrence of blood clots in certain cancer patients and during dialysis.
When should Dalteparin not to be taken? (Contraindications)
Hypersensitivity, active major bleeding, severe coagulation disorders; lumbar puncture; sympathetic block; brain, spinal cord, eye or ear surgery; severe hypertension.
What is the dosage of Dalteparin?
Subcutaneous- Unstable angina, Heart Attack- Adult: 120 IU/kg every 12 hour continued for 5-8 days with concomitant low-dose of aspirin. Max: 10,000 IU every 12 hours.
The recommended dose is 2500 IU to 5000 IU once daily for prophylaxis; 100uU/kg 12 hourly or 200 U/kg 24 hourly for treatment of DVT.
Extended Treatment of Symptomatic Venous Thromboembolism in Cancer Patients- Adults:Subcutaneous For the first 30 days of treatment, give 200 IU/kg once daily (max, 18,000 units/day). Months 2 to 6: Administer 150 IU/kg once daily (max, 18,000 IU/day).
Prophylaxis of clotting in extracorporeal circulation in haemodialysis or haemofiltration -Adult: 30-40 units/kg via IV injection, followed by an IV infusion of 10-15 units/kg/hour. A single dose of 5000 units may be given for haemodialysis or haemofiltration session lasting <4 hour. For patients at high risk of bleeding complications or who are in acute kidney failure: 5-10 units/kg via IV injection followed by an infusion of 4-5 units/kg/hour.
How should Dalteparin be taken?
It comes as a solution for injection, to be injected under the skin (Subcutaneously) by a healthcare provider.
What are the warnings and precautions for Dalteparin?
*Monitor coagulation time.*Caution needed for patients with history especially of: bleeding disorders, ulcers, liver disease, kidney disease, high blood pressure, heart disease, strokes, allergies (especially to heparin or pork). This medication should be used only if clearly needed during pregnancy or while breast-feeding.
What are the side effects of Dalteparin?
Skin- Hair loss, skin necrosis.Genitourinary- Blood in urine.
Blood- Any bleeding event, blood clot in the spine.
Hypersensitivity- Allergic reactions, including itching, rash, fever, injection-site reaction, hypersensitivity reactions.
Local- Injection-site blood clot, wound hematoma, injection-site pain.