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TB Bacteria Accumulate 'fat' to Survive and Spread
Researchers from the University of Leicester, together with colleagues from St Georges, University of London, funded principally by the Medical Research Council (MRC) and The Wellcome Trust, say that their findings challenge the established view that the TB bacteria coughed up in sputum by infected individuals are rapidly multiplying.
"Strenuous efforts are being made to reduce the global burden of tuberculosis, a disease which kills four people every minute. Our success so far has been limited for many reasons; one of these is our failure to control the spread of TB from one person to another. Very little is known about this vital part of the bacterium's life cycle," lead investigator Professor Mike Barer, Professor of Clinical Microbiology in the Department of Infection, Immunity and Inflammation at the University of Leicester said.
"If scientists could understand more about the transmission of TB between people, they might identify new therapeutic and preventative targets," he added.
The Leicester team discovered that, unlike TB bacteria growing in test tubes, many of the bugs in sputum are loaded with fat droplets. They went on to show with their colleagues in London that these 'fat bacilli' were in an inert non-growing state, a condition in which they are more likely to survive the process of passing from one person to another.
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