New Compounds With Potential Anti-depressant Activity Discovered

by Medindia Content Team on  February 22, 2008 at 12:36 PM Research News
RSS Email Print This Page Comment
Font : A-A+

New Compounds With Potential Anti-depressant Activity Discovered
A researcher of the University of Navarra has discovered new compounds with the potential for anti-depressant activity.

The researcher with the Drug R&D Unit of the University of Navarra, Luis Berrade, synthesized 51 compounds in the study.

The researcher explained that the new molecules designed by him affect two brain targets which are considered to be key in the development of processes of depression.

One of these is the serotonin transporter, whose reuptake reduction has already been shown to improve mood; the other is the serotoninergic receptor 5-HT7, a therapeutic target for serotonin whose modulation can provoke anti-depressant effects.

In order to study these two key targets, Luis Berrade developed chemical structures via the fusion of two similar chemical compounds: the benzo[b]-thiophene ring and arilamine.

Following this, he compared the new compounds with a drug currently on the market, Fluoxetine.

As a result of this research, he explained, we discovered that nine of these compounds demonstrated greater affinity, in this sense, than the commercial drug.

This study, one of the first in the world in this specialty, was undertaken in collaboration with the Department of Pharmacology of the University of Navarra.

The study's objective was to discover whether the new compounds could reduce the minimum time required for anti-depressant drugs to ameliorate the symptoms of the disease.

Source: ANI
SRM/L

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive