Gpx5 Protein Protects Sperm After It Leaves the Testes

by Tanya Thomas on  June 24, 2009 at 10:19 AM Men´s Health News
RSS Email Print This Page Comment
 Gpx5 Protein Protects Sperm After It Leaves the Testes
A newly-identified protein has been found to protect immature mouse sperm after they have been released into a region of the testis known as the epididymis, which is where they undergo maturation. Credit for this discovery goes yo Joel Drevet and colleagues, at Clermont Université, France.
Advertisement

Although male mice lacking this protein, Gpx5, had normal looking sperm and were equally as efficient as normal male mice at fertilizing female mice, an increased incidence of miscarriages and fetal developmental defects were observed when normal female mice were mated with Gpx5-deficient males over 1 year old compared with normal male mice of the same age.

Advertisement
Further analysis indicated that Gpx5 acts as an antioxidant in the epididymis, protecting the sperm from oxidative stress. As discussed by the authors, and, in an accompanying commentary, John Aitken, at the University of Newcastle, Australia, these data have immense clinical relevance as age-related DNA damage to human sperm has been associated with a range of adverse outcomes including decreased fertility, and increased rates of miscarriage and childhood disease.



Source: Eurekalert
TAN
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Genetics of Male Infertility Artificial Insemination Varicocele Premature Ejaculation Sex Numbers Diet and Nutrition Tips for Athletes Curry Leaves Health Benefits 
Advertisement

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive