How to Take Amifostine and Dose of Amifostine


Find out how to take Amifostine (drug) and its dose. Describes the best time to take the drug and precautions if any that should be followed.

How to take Amifostine


How it should be taken  

This medication available in the form of injection, administered by the healthcare providers.

Dosage & When it is to be taken

As a cell protective agent in chemotherapy and radiation.
Adult: Initially, 910 mg/m2 BSA once daily, as an infusion given over 15 minutes, 30 minutes before start of chemotherapy. May reduce to 740 mg/m2 if patient is unable to tolerate the full dose.
For patients receiving cisplatin- <100 mg/m2, a dose of 740 mg/m2 may be given to reduce renal toxicity.
Prophylaxis of dry mouth in patients undergoing radiotherapy for head and neck cancer- Adult: 200 mg/m2 BSA once daily, as an infusion given over 3 minutes, beginning 15-30 minutes before radiotherapy.

When it is not to be taken (Contraindications) 

Contraindicated in patients with low BP, dehydration, patients with kidney or liver disease, children and elderly >70 years, and hypersensitivity.

Why it is prescribed (Indications)  

This medication is a cytoprotective agent, prescribed for preventing kidney damage due to chemotherapy and reducing the mouth dryness due to radiation therapy. 

Pregnancy Category

Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Warnings and Precautions  

Caution needed for pregnant women and breast feeding.
Patients should drink water adequately to avoid dehydration.
Prolonged infusion causes greater side effects.
Stop antihypertensive drugs one day before infusion.
Take antiemetics (drug against vomiting and vomiting sensation) before infusion especially if the treatment causes vomiting.

Storage Conditions  

Intravenous: Vials containing lyophilized powder: Store at 20-25C. Reconstituted solution (500 mg/10 mL): Chemically stable for up to 5 hr at room temperature (about 25C) or up to 24 hr under refrigeration (2-8C).

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