Amoxapine/ Asendin - Drug Toxicity

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Latest prescription information about Amoxapine/ Asendin. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Drug Name : Amoxapine/ Asendin

Indication : Amoxapine is a tricyclic antidepressant.


Physiology : Amoxapine is a tricyclic antidepressant that is chemically distinct from amitriptyline and imipramine. Amoxapine is metabolized by the liver to 7-hydroxy and 8-hydroxy metabolites. The 8-hydroxyderivative is an active antidepressant with a half-life of 30 hours.

Normal Values : Amoxapine: 20-100 ng/ml (64-319 nmol/L). 8-OH-amoxapine: 150-400 ng/ml (478-1275 nmol/L). Both: 200-500 ng/mL (637-1594 nmol/L)

Critical Values : >500 ng/mL (> 1594 nmol/L).


Test Method : High Performance Liquid Chromatography (HPLC), Gas Chromatography (GC).

Side effects : The common side effects include drowsiness, dizziness , headache, blurred vision, dry mouth and tremor. Tardive dyskinesia (involuntary movements), suicidal tendency, heart arrhythmias (abnormal heart rhythms) also occur rarely. A serious adverse effect called neuroleptic malignant syndrome can also occur, which is a potentially fatal condition with symptoms of high fever, muscle rigidity, abnormalities in cardiac rhythm and alteration in mental status.

Related Drugs : 8-OH-amoxapine

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