Amiodarone/ Cordarone - Drug Toxicity

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Latest prescription information about Amiodarone/ Cordarone. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Drug Name : Amiodarone/ Cordarone

Indication : Amiodarone is an anti-arrhythmic drug.

Physiology : Amiodarone is a class III antiarrhythmic agent approved for the treatment of life threatening ventricular tachyarrhythmias. Because of the potential toxicity the serum level of this drug should be monitored.

Normal Values : 0.5-2.5 mg/L (>7 mmol/L).

Critical Values : Adverse effects at > 2.5 mg/L (>4 mmol/L).

Test Method : High Performance Liquid Chromatography (HPLC).

Side effects : Amiodarone results in lung toxicity which manifests as acute or subacute pneumonitis. The use of the drug is restricted because of its many side effects, including pulmonary fibrosis, exacerbation of heart failure, tremor, thyroid dysfunction, arrhythmia (abnormal heart rhythm), skin reactions, eye-related problems, peripheral neuropathy, liver damage and interaction with other drugs. Nerve-related and digestive tract-related side effects are extremely common.

Related Drugs : Liver profile, Thyroid Stimulating Hormone, Thyroxine

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What is amiodarone?

Amiodarone is an anti-arrhythmic medication which aids patients suffering from life-threatening ventricular and supraventricular rhythm disorders. This medication is applied in the case of ventricular tachycardia or ventricular fibrillation. Although amiodarone was discovered in 1961, it wasn't approved for medical applications till 1985, in the United States.
manuheart123  Saturday, January 22, 2011
Although the good spectrum of the Amidarone as Anti arrhythmic drugs it is not good for management of acute situation because its special pharmacokinetic properties as it needs about 4 to 5 its half life to begin work.
Mohamed  Sunday, August 3, 2008
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