While 65 percent of the US population is projected to be white in 2010, those numbers will start to decline around the 2030s as white deaths outpace births, according to the figures.
And by 2050, when the United States is projected to have a population of 439 million people, 54 percent of the population will be of racial minorities.
The largest growth will be among Hispanics, expected to be 133 million by 2050 -- almost a third of the projected US population growth between 2010 and 2050 -- due to high birth rates and immigration.
The Asian population will rise from 4.5 percent in 2010 to nearly 8 percent in 2050, but the non-Hispanic black population is expected to remain steady, going from 12.2 percent of the population in 2010 to 11.8 percent by 2050, the figures show.
The US population is also expected to be much grayer: currently some 38.7 million people in the United States are aged 65 or older, a figure that will rise to 88.5 million by 2050 boosted by the "baby boomers," those born in the post-World War II era (1946 to 1966).