About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Treating Heart Failure Requires an Integrated Study of the Heart, Spleen, and Kidney

by Anjali Aryamvally on November 16, 2017 at 11:53 AM
Font : A-A+

Treating Heart Failure Requires an Integrated Study of the Heart, Spleen, and Kidney

Heart failure after a heart attack is a global epidemic leading to chronic heart failure. About 6 million people in the United States and 23 million worldwide suffer end-stage heart failure.

Ganesh Halade, Ph.D., of the University of Alabama at Birmingham, says researchers not only need to look at events in the heart as they seek ways to improve post-heart attack healing -- they also need to examine simultaneous changes taking place in the spleen and kidneys.

Advertisement


Why? Because the three organs are linked in the disease process.

The spleen, which is 4 inches long and sits in the upper abdomen, acts as a reservoir of immune cells that speed to the site of heart injury after a heart attack to begin clearance of damaged tissue. Those leukocytes can lead to either heart protection or pathology, depending on how the immune response progresses.
Advertisement

In turn, the injury in the heart muscle after a heart attack develops a progressive signal that triggers structural pathology and complications in the kidneys, which can affect survival in heart attack patients.

Halade, who uses a mouse heart attack model to research ways to prevent heart failure, has now published a functional and structural compendium of the simultaneous changes taking place in the heart, spleen and kidneys in mice during the period of acute heart failure immediately following a heart attack and during the longer period of chronic heart failure that comes next. Such a systems biology study of heart-spleen and heart-kidney networks, also known as the cardiosplenic and cardiorenal networks, will be essential to developing novel treatments for chronic heart failure, says Halade, an assistant professor, UAB Department of Medicine and UAB Division of Cardiovascular Medicine.

In a study in the American Journal of Physiology-Heart and Circulatory Physiology, Halade and colleagues looked at functional and structural changes of the three organs at four time points: one day and five days after heart attack, which is the acute heart failure period in the mouse model, and 28 days and 56 days after heart attack, which is the chronic heart failure period. Fifty-six days after a heart attack for mice translates to about 10 years after a heart attack for humans.

The researchers looked at histological and structural changes in tissue slices from the three organs, and they used echocardiography to measure time-dependent functional changes in the left ventricle of the heart.

In correlation with changes in heart function, the UAB researchers found definite histological and cellular changes in the spleen, and they also found bimodal inflammatory responses in kidney inflammatory biomarkers. In the left ventricle of the heart, there was a unidirectional, progressive and irreversible deposition of compact collagen, along with dynamic changes in the cardiosplenic and cardiorenal networks following the heart attack.

"The renal histology and injury markers suggest that cardiac injury triggers irreversible dysregulation that actively alters the cardiosplenic and cardiorenal networks," Halade said. "Therefore, novel strategies or pathways that modulate comprehensive cardiosplenic and cardiorenal networks during acute heart failure or chronic heart failure could be an effective approach to study either cardiac repair or cardiac pathology."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
Long-Term Glycemic Control - A Better Measure of COVID-19 Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Congenital Heart Disease Kidney Disease Heart Kidney Healthy Heart Kidney Health Stones in Urinary Tract 

Recommended Reading
Congestive Heart Failure
Congestive heart failure (CHF) is a condition in which the heart fails to work adequately as a pump ...
Cardiac Pacemaker for Abnormal Heart Rhythms
A pacemaker stimulates the heart with electrical signals when it detects arrhythmias of the heart. ....
Cardiogenic Shock
Cardiogenic shock is defined as reduced cardiac output due to inability of the heart to pump ......
CoQ10
Vitamin-like CoQ10 helps generate energy for the cells to function at their optimum level. ......
Congenital Heart Disease
Heart diseases that are present at birth are called “ Congenital heart diseases”....
Hydronephrosis / Antenatal Counseling
Currently most pregnant women undergo one or two ultrasound scans during their pregnancy....
Stones in Urinary Tract
Ask people who have suffered from urinary stones and they will tell you how excruciating the pain ca...
Urinary Stones In Children
There is a wide misconception that only adults develop stones. On the contrary kidney stones are ver...
Vesico-Ureteric Reflux Causing UTI in Children
Bacterial infection of urinary bladder can cause pain and burning sensation while passing urine. Abn...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use