A 38-year-old patient from Kerala, Binu Nettikardan, who suffered from a rare blood disorder called hemophilia, where the blood does not clot, underwent a complicated open-heart surgery at MIOT International hospital, Chennai.
Two months ago, Binu complained of chest pain while coughing. He was diagnosed with aneurysm; most doctors were hesitant to operate on him as he has hemophilia.
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Binu was referred to MIOT International, where, V.V. Bashi, Chairman of Center for Thoracic and Cardiovascular Care, worked with doctors from six different specialties to find a way to operate on him.
Dr. Bashi, said, "The patient came in with a large aneurysm of the ascending aorta, and a leak in the aortic valve. This procedure needs an open heart surgery, but with haemophilia, even the smallest mistake can cause the patient to bleed to death."
![Hemophilia in Animals Corrected by Genome Editing]( "Hemophilia in Animals Corrected by Genome Editing")
Scientists have treated the blood clotting disorder hemophilia in mice by using an innovative gene therapy technique called genome editing
A team of six specialists performed a seven-hour surgery. The aorta was replaced with a permanent Dacron graft made of synthetic material because metal or titanium grafts have to be replaced after 10 to 12 years.
"The patient was connected to a heart-lung machine, his heart was stopped, and the ascending aorta replaced with a synthetic graft. The patient's valve was repaired and re-implanted into the artificial graft," said DR. Bashi.
The patient was injected with 2,200 units of anti-hemophilic drug two hours before the surgery. During the surgery, 7,000 units of anti-hemophilic drug were administered every hour to address the issue of blood not clotting.
Doctors claimed this was the first time in the world that a patient with hemophilia had undergone an open-heart surgery. Binu can now lead a normal life and he will be discharged in a day or two.
Source: Medindia
Hemophilia in Animals Corrected by Genome Editing
Scientists have treated the blood clotting disorder hemophilia in mice by using an innovative gene therapy technique called genome editing
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A team of six specialists performed a seven-hour surgery. The aorta was replaced with a permanent Dacron graft made of synthetic material because metal or titanium grafts have to be replaced after 10 to 12 years.
"The patient was connected to a heart-lung machine, his heart was stopped, and the ascending aorta replaced with a synthetic graft. The patient's valve was repaired and re-implanted into the artificial graft," said DR. Bashi.
The patient was injected with 2,200 units of anti-hemophilic drug two hours before the surgery. During the surgery, 7,000 units of anti-hemophilic drug were administered every hour to address the issue of blood not clotting.
Doctors claimed this was the first time in the world that a patient with hemophilia had undergone an open-heart surgery. Binu can now lead a normal life and he will be discharged in a day or two.
Source: Medindia
Trial of Gene Therapy Treatment of Hemophilia B Shows Promise
Four hemophilia B patients in a gene therapy trial using a vector that is being developed to correct the inherited bleeding disorder have shown no toxicity,report investigators.
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 FDA Starts Review of Biogen’s Therapy for Hemophilia BThe US Food and Drug Administration is currently reviewing Biogen Idec's application for a fusion protein therapy. | Advertisement
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