About My Health Careers Internship MedBlogs Contact us

Therapeutic Target for Liver Diseases Identified

by Rajashri on August 4, 2008 at 3:19 PM
Font : A-A+

 Therapeutic Target for Liver Diseases Identified

A protein called FOXA2 plays an important role in maintaining the proper level of bile in the liver, a new study by US researchers has found.

Experts at the University of Pennsylvania School of Medicine claim that their finding suggests that FOXA2 may become the focus for new therapies to treat diseases that involve the regulation of bile salts.


After its formation in the liver, bile gets stored in the gall bladder, and transported through ducts to the small intestine where it helps to digest fats from food.

Chemicals in bile that help digest fats and keep cholesterol dissolved are called bile salts. The liver maintains their balance by degrading old bile salts and synthesizing new ones.

Problems arise when too many bile salts accumulate in the liver.

The researchers say that diseases of bile regulation, like primary sclerosing cholangitis (PSC), are characterized by problems with bile transport from the liver to the gut.

In children with biliary atresia and adults with PSC, they have found that the expression of FOXA2 in the liver is severely reduced.

According to them, FOXA2 regulates the expression of transporter proteins that are responsible for moving bile out of the liver, as well as several enzymes that function in bile acid detoxification.

Based on their observations, the researchers came to the conclusion that low FOXA2 levels exacerbate liver injury.

The researchers believe that medications or DNA therapies that increase the expression of FOXA2 in liver cells may offer a new means of treating PSC and other similar syndromes.

"In order to lay the groundwork for developing new treatments, we have to determine how FOXA2 itself is regulated," Nature magazine quoted first author Irina Bochkis, a doctoral student in Genomics and Computational Biology, as saying.

Source: ANI

News A-Z
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Hepatitis A Liver Wilson's Disease Biliary Cirrhosis Milk Thistle Current Treatments for Liver Cancer Fatty Liver Disease: A Growing Health Problem in India Living Donor Liver Transplant: What Are the Risks? Health Risks of Eating Pork Hepatorenal Syndrome 

Recommended Reading
Alcoholic Liver Disease
Encyclopedia section of medindia gives general information about Alcoholic Liver Disease....
Liver Cancer - Animation
Liver is the largest organ inside the human body. It performs 500 different functions and processes ...
Natalie Cole Suffering from Hepatitis C
Singer Natalie Cole has confirmed that she is suffering from the chronic liver disease Hepatitis C....
Biliary Cirrhosis
Biliary cirrhosis occurs due to obstruction to the flow of bile through bile ducts either within the...
Current Treatments for Liver Cancer
Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result ...
Fatty Liver Disease: A Growing Health Problem in India
Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is...
Health Risks of Eating Pork
Pork is one of the most popular and widely consumed of all red meats, but how healthy is it? Find ou...
Hepatitis A
Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. H...
Hepatorenal Syndrome
Hepatorenal syndrome (HRS) occurs in end stage cirrhosis and is marked by serious circulatory distur...
Living Donor Liver Transplant: What Are the Risks?
The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk ...
Milk Thistle
Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication ...
Wilson's Disease
This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before o...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use