Transcriptomics and biochemical evidence of trigonelline ameliorating learning and memory decline in the senescence-accelerated mouse prone 8 (SAMP8) model by suppressing proinflammatory cytokines and elevating neurotransmitter release
Go to source). Trigonelline (TG), a plant alkaloid found in coffee, as well as in fenugreek seed and radish, was anticipated to possess cognitive enhancement properties.
Coffee, Caffeine and Your Health
Caffeine sensitivity decides if coffee is good or bad for you. However drinking coffee preferably without caffeine may be good for your health.
Caffeine sensitivity decides if coffee is good or bad for you. However drinking coffee preferably without caffeine may be good for your health.
‘In the pursuit of natural remedies to combat age-related cognitive decline, recent research has spotlighted the importance of promoting healthy aging using an alkaloid found in coffee, fenugreek seeds, and radishes — Trigonelline (TG).
#Coffee, #Trigonelline, #Cognition
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In this study, researchers led by the University of Tsukuba investigated the effects of TG on memory and spatial learning (acquiring, retaining, structuring, and applying information related to the surrounding physical environment) from both a cognitive and molecular biology perspective in an integrated manner using a senescence-accelerated mouse prone 8 (SAMP8) model. Following oral administration of TG to SAMP8 mice for 30 days, the Morris water maze test indicated a significant improvement in spatial learning and memory performance compared with SAMP8 mice that did not receive TG.
The Natural Brain Booster
Next, the researchers performed a whole-genome transcriptomic analysis of the hippocampus to explore the underlying molecular mechanisms.They found that signaling pathways related to nervous system development, mitochondrial function, ATP synthesis, inflammation, autophagy, and neurotransmitter release were significantly modulated in the TG group.
Health Benefits of Drinking Green Coffee
Green coffee (unroasted coffee beans) contains a host of natural antioxidants that may help manage diabetes, reduce high blood pressure (hypertension) and promote healthy weight loss.
Green coffee (unroasted coffee beans) contains a host of natural antioxidants that may help manage diabetes, reduce high blood pressure (hypertension) and promote healthy weight loss.
Additionally, quantitative protein analysis confirmed that the levels of inflammatory cytokines TNF-α and IL-6 were significantly decreased and the levels of neurotransmitters dopamine, noradrenaline, and serotonin were significantly increased in the hippocampus. These findings suggest the efficacy of TG in preventing and improving age-related spatial learning memory impairment.
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Coffee
Coffee is a great beverage prepared from the seeds of Coffea plant. Different types of coffee include espresso, cappuccino, Café latte, frappe, iced coffee.
Coffee is a great beverage prepared from the seeds of Coffea plant. Different types of coffee include espresso, cappuccino, Café latte, frappe, iced coffee.
- Transcriptomics and biochemical evidence of trigonelline ameliorating learning and memory decline in the senescence-accelerated mouse prone 8 (SAMP8) model by suppressing proinflammatory cytokines and elevating neurotransmitter release - ( https://link.springer.com/article/10.1007/s11357-023-00919-x)
Source-Eurekalert
Nutrition Value in Celery Leaves
Important values in 100 grams of CELERY LEAVES like energy, moisture, protein, fat, carbohydrates, fibre, calcium, Iron and Phosphorus
Important values in 100 grams of CELERY LEAVES like energy, moisture, protein, fat, carbohydrates, fibre, calcium, Iron and Phosphorus
