A new study has reported anti-microbial antibody formation in celiac disease. Relatively high positivity rates were observed for the conventional antibodies, for example, ASCA, anti-OmpW, and anti-I2, and they were known to decrease after a successful gluten free-diet. The importance of newly discovered inflammatory bowel disease-associated antibodies (including anti-glycan antibodies and anti-OMP) in celiac disease is not sure. The presence of anti-microbial antibodies in relation to clinical presentation of the disease and NOD2/CARD15 mutations was also not investigated. A research article to be published on August 21, 2009 in the World Journal of Gastroenterology addresses this question. Hungarian researchers from the University of Debrecen in Debrecen and the Semmelweis University in Budapest have shown in a well-characterized CD cohort that the anti-glycan antibody positivity is a common feature of celiac disease at the time of diagnosis and is lost after long-term gluten-free diet. The positivity rate and titers at diagnosis are as high as observed in Crohn's disease. The presence of anti-glycan antibodies is associated with the presenting symptoms, especially with severe malabsorption but not with mutations in NOD2/CARD15. No higher prevalence of anti-microbial antibodies is observed in the unaffected, first-degree relatives of this patient cohort. Although the new data presented in the article may add new pieces to the puzzle of the anti-microbial antibody formation, the authors believe that it also assist to re-evaluate recently proposed genetically drived mechanism. Serological response to various microbial antigens might be considered a universal marker of the enhanced translocation of the gut microflora through the impaired small bowel mucosa both in celiac and Crohn's disease patients. Source: EurekalertRAS << Research Finds Potential Therapeutic Agent for Hepatic Fibr... Experts Say Tamiflu Must be Administered Within Two Days >> Recommended Reading Kawasaki Disease Kawasaki disease affects the children that involve the skin, mouth and blood vessels. It can be treated with acetaminophen, aspirin and intravenous gamma globulin. READ MORE Alzheimers Disease Alzheimer's disease is a progressive neurodegenerative disease affecting memory and thinking and making the person increasingly dependent on others. READ MORE Alcoholic Liver Disease Encyclopedia section of medindia gives general information about Alcoholic Liver Disease. READ MORE Mosquito Diseases Mosquito-borne diseases, like malaria, filaria, dengue, etc are common in places conducive of mosquito breeding. Swamps, ponds and stagnated drainage provide optimal breeding ground for mosquitoes. READ MORE Celiac Disease Celiac disease is labeled as a digestive disorder associated with malabsorption as well as an abnormal immune reaction to gluten. READ MORE Food Preservatives - How Safe Are They? Food preservatives are basically antimicrobials or anti-oxidants that help preserve food by destroying the microbes and stopping decomposition of food products. READ MORE Most Popular on Medindia Pregnancy Confirmation Calculator Turmeric Powder - Health Benefits, Uses & Side Effects Noscaphene (Noscapine) More News on: Celiac DiseaseFood Preservatives - How Safe Are They?