Wild-blueberry diets may help prevent pathologies associated with the metabolic syndrome, including cardiovascular disease and diabetes, reveals study.
This new research, published today in the journal Applied Physiology, Nutrition, and Metabolism.
"The metabolic syndrome (MetS) is a group of risk factors characterized by obesity, hypertension, inflammation, dyslipidemia, glucose intolerance and insulin resistance, and endothelial dysfunction," explains Dr. Klimis-Zacas, a Professor of clinical nutrition at the University of Maine and a co-author of the study. "MetS affects an estimated 37% of adults in the US ." Many substances found in food have the potential to prevent MetS, thus reducing the need for medication and medical intervention.
"We have previously documented the cardiovascular benefits of a polyphenol-rich wild blueberry in a rat model with impaired vascular health and high blood pressure," says Klimis-Zacas. "Our new findings show that these benefits extend to the obese Zucker rat, a widely used model resembling human MetS."
"Endothelial dysfunction is a landmark characteristic of MetS, and the obese Zucker rat, an excellent model to study the MetS, is characterized by vascular dysfunction. The vascular wall of these animals shows an impaired response to vasorelaxation or vasoconstriction which affects blood flow and blood pressure regulation."
According to the study, wild blueberry consumption (2 cups per day, human equivalent) for 8 weeks was shown to regulate and improve the balance between relaxing and constricting factors in the vascular wall, improving blood flow and blood pressure regulation of obese Zucker rats with metabolic syndrome.
"Our recent findings reported elsewhere, documented that wild blueberries reduce chronic inflammation and improve the abnormal lipid profile and gene expression associated with the MetS." Thus, this new study shows even greater potential such that "by normalizing oxidative, inflammatory response and endothelial function, regular long-term wild blueberry diets may also help improve pathologies associated with the MetS."