Skin vaccination generates protective CD8 T-cells that are recruited to the genital tissues. Study conducted by King's College London scientists has revealed how the skin vaccination strategy could be used against sexually transmitted diseases. The findings of the study are published in the Nature Communications. One of the challenges in developing vaccines for STIs, such as HIV or herpes simplex virus, is understanding how to attract specialised immune cells, called CD8 T-cells, to take up residence in the part of the body where the virus first enters. These cells need to be in place, armed and ready to provide an immediate protective immune defence, rather than waiting for immune cells in the blood to enter the tissues which takes time. Before this study, it was thought that vaccines ideally needed to be delivered directly to the body surface (e.g. female genital tissue) where the infection might start, so that the immune system can generate these CD8 T-cells, travel back to the vaccination site and eliminate any future virus that is encountered. However, delivering vaccines directly to the female genital tissue is neither patient friendly nor efficient. ‘Specialized groups of 'innate' immune cells in distant tissues can be harnessed to attract protective CD8 T-cells, arming the body's frontline tissues from infection.’ Now the team from King's have found that their vaccination strategy marshals a platoon of immune cells, called innate lymphoid cells (ILC1) and monocytes, in the genital tissues to work together and release chemicals (chemokines) to send out a call to the CD8 T-cells generated by the vaccine to troop into the genital tissue. This research builds on the team's earlier work to develop skin vaccination techniques using a dissolvable 'microneedle' vaccine patch that once placed against the skin dissolves and releases the vaccine without requiring a hypodermic needle injection and generates immune responses. "We now need to confirm these results with other types of vaccines from the one used in the study to see if a common pathway is triggered by skin vaccination. If proven, this could have a significant impact in improving the effectiveness of vaccines against sexually transmitted infections." Source: Eurekalert << Brain Network Activity Helps Epileptic Patients Button Batteries can Rapidly Damage Stomach Lining >> Recommended Reading Immunization Protect your child from various deadly diseases by giving the vaccinations at the right age. This tool helps you schedule the vaccinations of your child. READ MORE Prostitution: Fresh Stakes in the Oldest Trade Prostitution has broadened its base to include street prostitution, massage brothels, gigolo outcall services, strip clubs, lap dancing, phone sex, child prostitution and sex tourism. READ MORE Syphilis Syphilis is a sexually transmitted disease caused by the spirochete bacterium. Syphilis can be passed from mother to her baby during pregnancy. READ MORE Traveling with Children Abroad? - Parents, Stay Alert! Traveling with children is always challenging as it involves careful planning. Here are some precautions that need to be taken when traveling abroad with kids. READ MORE Most Popular on Medindia Fongitar (Zinc Pyrithionone) Color Blindness Calculator Diaphragmatic Hernia More News on: SyphilisProstitution: Fresh Stakes in the Oldest TradeSafe SexTraveling with Children Abroad? - Parents, Stay Alert!