About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Scientists Identify Genes That Enhances Response to CopaxoneŽ in MS Patients

by Medindia Content Team on October 17, 2007 at 3:28 PM
Font : A-A+

Scientists Identify Genes That Enhances Response to CopaxoneŽ in MS Patients

Researchers from the Technion - Israel Institute of Technology, the Weizmann Institute of Science and Teva Pharmaceutical Industries have identified the genes responsible for eliciting positive outcomes in multiple sclerosis patients to the drug CopaxoneŽ. These findings may contribute to the development of personalized medicine for multiple sclerosis sufferers.

CopaxoneŽ was the first original Israeli drug to be approved by the U.S. Food and Drug Administration (FDA), and is today marketed in over 40 countries worldwide, including the U.S.A., Europe, Australia, Latin America and Israel.

Advertisement

The drug molecule was the fruit of research by Prof. Michael Sela, Prof. Ruth Arnon and Dr. Dvora Teitelbaum of the Weizmann Institute's Immunology Department. It was developed for the treatment of multiple sclerosis (MS) by Teva, which produces and markets CopaxoneŽ today.

'Until now, medical treatments for all kinds of diseases have relied on trial and error methods to determine dosage and treatment protocols,' says Prof. Ariel Miller of the Ruth and Bruce Rappaport Faculty of Medicine at the Technion, and Head of the Multiple Sclerosis and Brain Research Center, Carmel Medical Center, Haifa. 'But the process of fixing the correct dosage affects the efficacy of the treatment and can lead to complications in some cases.' In the past few years, it has been shown that many drugs are not equally effective for every patient, and this variability is due, at least in part, to genetic differences. Finding medications and doses to suit the genetic make-up of each individual patient is likely to be more successful and to cause fewer side effects.
Advertisement

The new research, which deals with the genetic components of the response to CopaxoneŽ, was recently published in the journal Pharmacogenetics and Genomics. It represents a significant step toward realizing this medical vision. In the collaborative study, Teva supplied DNA samples from drug-treated patients, and the genetic tests were performed at the Crown Human Genome Center of the Weizmann Institute, headed by Prof. Doron Lancet of the Institute's Department of Molecular Genetics. The scientists used state-of-the-art equipment - the first of its kind in Israel, which allows for the rapid and accurate scanning of variations in the human genome. The scientists then examined the links between the genetic markers they found and the response of MS patients to CopaxoneŽ. They identified several genes that are tied to a positive response to the drug. 'We analyzed the DNA sequences in 27 candidate genes from each patient participating in the trial,' said Lancet, 'and we identified two genes with a high potential for determining the response to CopaxoneŽ. In the future, it may be possible to use this method to scan the genome of MS sufferers, to predict the response levels in advance, and to optimize the dosage and treatment protocol to suit each patient personally.

Source: Eurekalert
GAN/V
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
Long-Term Glycemic Control - A Better Measure of COVID-19 Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Weaver Syndrome 

Recommended Reading
Tackling Multiple Sclerosis Earlier On Slows Progression
According to a study in the Lancet, early use of the drug interferon beta-1b can significantly ......
Weaver Syndrome
Weaver syndrome is a genetic disorder in which children show accelerated bone growth, advanced bone ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use