A compound found in fish oil which kills leukemia stem cells may hold the key to its cure, according to Penn State researchers.
The compound -- delta-12-protaglandin J3, or D12-PGJ3 -- targeted and killed the stem cells of chronic myelogenous leukemia, or CML, in mice, said Sandeep Prabhu, associate professor of immunology and molecular toxicology in the Department of Veterinary and Medical Sciences.
The compound is produced from EPA -- Eicosapentaenoic Acid -- an Omega-3 fatty acid found in fish and in fish oil, he said."Research in the past on fatty acids has shown the health benefits of fatty acids on cardiovascular system and brain development, particularly in infants, but we have shown that some metabolites of Omega-3 have the ability to selectively kill the leukemia-causing stem cells in mice," said Prabhu.
Specifically, it activates a gene -- p53 -- in the leukemia stem cell that programs the cell's own death."p53 is a tumor suppressor gene that regulates the response to DNA damage and maintains genomic stability," Prabhu said.