About Careers Internship MedBlog Contact us

Popular Breast Cancer Drug ‘could Make Disease More Aggressive’

by VR Sreeraman on December 5, 2008 at 3:00 PM
 Popular Breast Cancer Drug ‘could Make Disease More Aggressive’

For some women, a leading breast cancer drug, called Tamoxifen, could make the disease more aggressive, according to scientists.

Considered as a "gold standard" for breast cancer treatment, Tamoxifen has been used to combat the disease for more than 20 years and has been credited with saving the lives of around 20,000 women since the 1980s.


But now, scientists have conducted laboratory tests on cancer cells grown in test tubes and found evidence indicating that giving Tamoxifen to some patients could actually promote the disease.

It was found that adding Tamoxifen to cancer cells which contained low levels of a naturally-produced protein, called E-cadherin, caused the cells to behave more aggressively.

Lead researcher, Dr Stephen Hiscox, from the Welsh School of Pharmacy at Cardiff University, said that they were unaware of the percentage of patients who would have low levels of the protein in their bodies.

"Certainly the vast majority appear to have normal levels," The Telegraph quoted him as saying.

He added: "Also, we do not at this stage know what level is low enough for this effect to kick in, or indeed whether there is the same effect in humans as we are finding in laboratory tests."

Currently, the researchers are examining samples from breast cancer patients to try to work out what proportion of women have low levels of the protein.

He claimed that such patients could potentially be treated instead with a new class of drugs, called aromatase inhibitors, which target the cancer differently by depriving the body of oestrogen, which helps to fuel the growth of tumours.

According to the scientists Tamoxifen could react with low levels of E-cadherin in the body and elevate the amount of another protein, called SRC.

In earlier studies, SRC was shown to affect breast cancer cells to make them behave more aggressively.

The study is published in the journal Breast Cancer Research.

Source: ANI
Font : A-A+



Recommended Readings

Latest Diet & Nutrition News

Science's Solutions to Beat a Hangover
New study shares scientific rescues from the post-party hangover blues after heavy alcohol consumption.
Saturated Fat Linked to Memory Impairment in Aging Brain
Study investigated the impact of a saturated fat-rich diet on brain signaling in older mice by studying a microglial function known as synaptic pruning.
Are Your Omega-3 Fish Oil Pills Healthy or Harmful?
Flavored omega-3 fatty acid supplements can conceal its rancidity, lowering its health benefits and obscuring health hazards.
The Coffee Alkaloid That Rewires Your Brain
Alkaloid extracted from coffee proves its mettle in enhancing cognitive abilities and counteracting age-related cognitive decline.
Therapeutic Effects of Ginger in Autoimmune Diseases
Fresh findings bolster the case for utilizing ginger supplements in the management of autoimmune disorders.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
Greetings! How can I assist you?MediBot

Popular Breast Cancer Drug ‘could Make Disease More Aggressive’ Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests