Over-The-Counter Vitamin-Like Substance In High Doses May Slow Parkinson’s Progress

In a large-scale clinical trial in US and Canada, researchers at Rush University Medical Center are trying to find out if an over-the-counter vitamin-like substance, in high doses,

In a large-scale clinical trial, researchers are trying to find out if an over-the-counter vitamin-like substance, in high doses, can slow the progression of Parkinson's disease.

The clinical trial is being done by researchers at Rush University Medical Center.

Parkinson’s Disease - Causes, Symptoms, Diagnosis, Treatment
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. Symptoms of Parkinson’s disease are correctable to an extent.

The substance being tested, called coenzyme Q10, is produced naturally in the body and is an important link in the chain of chemical reactions that produce energy in mitochondria, the "powerhouses" of cells.

The enzyme is also a potent antioxidant - a chemical that "mops up" potentially harmful chemicals generated during normal metabolism.

"At present, the very best therapies we have for Parkinson's can only mask the symptoms - they do not alter the underlying disease. Finding a treatment that can slow the degenerative course of Parkinsons's is the holy grail of Parkinson's research," said neurologist Dr. Katie Kompoliti, a specialist in movement disorders.

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Many past studies have shown that Parkinson's patients have impaired mitochondrial function and low levels of coenzyme Q10.

Moreover, laboratory research has demonstrated that coenzyme Q10 can protect the area of the brain damaged in Parkinson's.

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The Phase III clinical trial, a large, randomized study with a control group, follows an earlier investigation that tested several doses of coenzyme Q10 in a small group of patients with early-stage Parkinson's disease.

The highest dose, 1,200 mg, appeared promising-over the course of 16 months, patients taking this dose experienced significantly less decline than other patients in motor (movement) function and ability to carry out activities of daily living, such as feeding or dressing themselves.