Medindia
Advertisement

New Treatment to Fight 2 Bone Diseases Discovered

by Adeline Dorcas on August 2, 2019 at 3:56 PM

New Treatment to Fight 2 Bone Diseases Discovered
New study offers fresh hope for patients suffering from two rare bone diseases - heterotopic ossification (HO) and fibrodysplasia ossificans progressiva (FOP). The findings of the study could pave the way for improving the treatment for these two bone diseases.

  • The study describes the ability of a PI3-kinase inhibitor to combat Heterotopic Ossification and Fibrodysplasia Ossificans Progressiva in murine preclinical models
  • These results could have an impact on the treatment of patients with these diseases

A team of researchers from the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona (UB) have described the ability of an inhibitor of the PI3Kú\ (BYL719) to block the ectopic bone formation in mice. This could lead to improve the treatment of two pathologies: heterotopic ossification and fibrodysplasia ossificans progressiva (FOP, a rare bone disease). The study was led by Dr. Francesc Ventura, head of the Cell Signaling and Bone Biology group.
Advertisement


Heterotopic ossification (HO) consists in the appearance of ossifications in inappropriate places (ectopic formation), such as tendons, muscles, and connective tissue. For this pathology, there are risk factors such as prolonged immobility, spinal injuries, burns, hip operations, and muscle traumas.

"Despite knowing this we still do not have a full understanding of the causes and the most appropriate treatment for the disease," says Dr. Francesc Ventura.
Advertisement

On the other hand, the FOP is a rare disease very similar to HO but has its origin in a genetic mutation. FOP patients have mutations in the gene encoding a bone growth factors receptor (BMPs), the ACVR1. The disease is gradually induced by episodes of inflammation that eventually result in the progressive formation of bone in muscles, tendons, and ligaments. These ossifications reduce drastically the mobility and life expectancy of those affected. There is currently no treatment for this disease.

"What we have observed in this study is that, in stem cells cultures and in preclinical models of the disease, the BYL719 inhibitor prevents the ectopic bone formation induced by mutations in ACVR1," explains Dr. Ventura.

The BYL719 inhibitor was approved by the FDA last May for its use in patients with metastatic breast cancer. Therefore, there is a large amount of information about the use of BYL719 in humans.

"In this study, we have shown that it can also play an important role in the ossification and treatment of these bone diseases," adds Ventura.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Infantile Cortical Hyperostosis Renal Osteodystrophy / Mineral Bone Disorder Neck Cracking 

Recommended Reading
New Potential Target for the Diagnosis and Treatment of Bone Diseases
Loss of a key protein leads to defects in skeletal development including reduced bone density and .....
Fibrous Dysplasia
Fibrous dysplasia is a condition with abnormal growth areas in one or more bones, where normal bone ...
Blame Your Genes for Bone Disease
After 10-years of research the scientists have found several new genes which are responsible for ......
Blood Samples from NASA Astronauts Help Scientists Develop Real-Time Bone Disease Test
By using calcium isotope ratios 42Ca and 44Ca in bone, healthcare providers may be able to optimize ...
Infantile Cortical Hyperostosis
Infantile Cortical Hyperostosis is a disease of unknown cause, where bizarre thickening of the corti...
Neck Cracking
Neck cracking or neck popping is caused by quick movements to loosen the ligaments and joints of the...
Renal Osteodystrophy / Mineral Bone Disorder
Renal Osteodystrophy which is referred to as Mineral Bone Disorder is a result of imbalance in calci...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use