Medindia
Advertisement

New Targets in Neurodegenerative Disorders Discovered

by Colleen Fleiss on December 28, 2018 at 3:07 AM
Font : A-A+

New Targets in Neurodegenerative Disorders Discovered

Autophagy on the neuronal cells leads to neurodegenerative diseases and countering the effects of this process through targeted medications can be beneficial in the fight against neurodegenerative diseases, said researchers.

Autophagy is a cellular degradation process that can cause the death of a cell in certain conditions. Autophagy is necessary to maintain cellular homeostasis by clearing out damaged cellular organelles and proteins through certain pathways. Mitochondria are cell organelles responsible for the constant supply of energy to maintain cellular physiology and energy metabolism.

Advertisement

Ashutosh Kumar et al. at the National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India present a review on autophagy in neuronal cells. Neuronal cells are more vulnerable to such bioenergetic depletion as most of their function crucially depends on availability of energy derived mainly from mitochondrial function. Any incidence of mitochondrial dysfunction inevitably results in neurodegeneration. Therefore, mitochondrial autophagy (mitophagy) plays an integral role in the onset of neurodegenerative diseases as the instance and failure of these pathways can have destructive effects on cellular homeostasis.

Previous studies show significant association between neurodegenerative disorders and mitochondrial dysfunction and abnormal mitophagy. Abnormal mitophagy leads to the accumulation of protein aggregates and consequential neurodegeneration. Future treatments for neurodegenerative disorders could involve drugs targeting mitochondria and autophagy-related proteins and enzymes.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Gonorrhea
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Spinocerebellar Ataxia 

Recommended Reading
Autophagy: Self-Repair Mechanism at Cellular Level
Autophagy, initiated by cellular stress and starvation is the cell's self-repair mechanism and ......
Huntington´s Disease
Huntington's disease is a genetic degenerative disorder that affects the brain and causes ......
Quiz on Parkinson’s Disease
Parkinson's disease is a disease of the central nervous system. Here's an interesting quiz to find ....
Caring for Alzheimers disease patients
Alzheimer's disease is a complex brain disorder that triggers the most common form of dementia. The ...
Spinocerebellar Ataxia
Spinocerebellar ataxia (SCA) is a progressive, neurodegenerative, genetic disease, which has no cur...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use