About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Novel Approach to Treat Ovarian Cancer

by Dr. Enozia Vakil on June 1, 2013 at 11:53 PM
Font : A-A+

 New Novel Approach to Treat Ovarian Cancer

A novel, targeted approach to chemotherapy that makes ovarian cancer cells more susceptible to the cytotoxic effects of an antitumor drug, may offer a much more safer and effective treatment. The research and results are published in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers (http://www.liebertpub.com). The article is available on the Nucleic Acid Therapeutics website (http://www.liebertpub.com/nat).

Ovarian cancer is usually diagnosed at an advanced stage of disease, and although most patients initially respond to conventional chemotherapeutic agents, the cancer typically recurs and the overall survival rate is poor. Furthermore, current chemotherapeutics for ovarian cancer are nonspecific and generally toxic causing debilitating side effects. More effective and specific agents are needed that target ovarian cancer cells and inhibit their ability to reproduce.

Advertisement

Sibaji Sarkar and Douglas Faller, Boston University School of Medicine (Boston, MA), successfully advanced their research to develop anti-tumor drugs comprised of nucleic acids, the building blocks of DNA. They had previously shown that so-called "GT-oligos" (which target and bind to nucleic acid sequences present in regions found at the ends of chromosomes, called telomeres) can trigger cell death in certain types of cancer cells, including ovarian, pancreatic, and prostate cancer. However not all cancer cells in these and other tumor types are susceptible to the effects of GT-oligos.

In the current study the authors take this work a step further and demonstrate a novel method to sensitive resistant ovarian cancer cells to this targeted chemotherapeutic approach. They describe the details of this strategy and the potential to apply this technique more broadly to treat other types of epithelial cancers in the article " Telomere-Homologous G-rich Oligonucleotides Sensitize Human Ovarian Cancer Cells to TRAIL-Induced Growth Inhibition and Apoptosis." (http://online.liebertpub.com/doi/full/10.1089/nat.2012.0401)
Advertisement

"The devastating mortality rate from ovarian cancer has not changed since the 'War on Cancer" was declared in 1971," says Executive Editor Fintan Steele, PhD, SomaLogic, Inc., Boulder, CO. "We need to improve both early diagnosis and find novel treatments. The work by Sarker and Faller provides a new and promising approach for treatment of this particularly difficult form of cancer."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Ovarian Cancer Cancer and Homeopathy Cancer Facts Cancer Tattoos A Body Art Meigs Syndrome Ovarian Pain Premature Ovarian Failure 

Recommended Reading
US Budget Cuts Block Advances: Cancer Researchers
The federal budget cuts enacted by the US Congress could block key advances in the fight against ......
Meigs Syndrome
Meigs'' syndrome is a medical condition with a triad of symptoms including benign ovarian tumor, asc...
Ovarian Cancer
Ovarian cancer affects both the ovaries and is referred to as the ''silent killer'' as the symptoms ...
Ovarian Pain
Ovarian pain is caused due to various conditions like ovarian cysts, ovarian tumors, endometriosis, ...
Premature Ovarian Failure
Premature menopause is ovarian failure which occurs 2 SD in years before a mean menopausal age and p...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use