![New Drug Reduces Fibrosis and Prevents DMD New Drug Reduces Fibrosis and Prevents DMD](https://images.medindia.net/health-images/1200_1000/Inverted-Microscope.jpg)
‘A new drug REV-ERB appears to play unique roles for each stage of muscle tissue development and prevents loss of muscle function in an animal model of DMD.’
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With treatment, those with DMD have an average lifespan of around 25 years. Boys with the illness typically need to use a wheelchair by age 12 and require mechanical ventilation to help with breathing. ![twitter](https://images.medindia.net/icons/news/social/twitter.png)
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Many eventually suffer cardiac or respiratory failure.
Thomas Burris and Colin Flaveny from Saint Louis University aim to develop synthetic compounds to target these receptors in order to create drugs to treat diseases by understanding how the body’s natural hormones operate.
"Recently, we found that REV-ERB appears to play unique roles for each stage of muscle tissue development," Flaveny said.
REV-ERB regulates key processes in the body, from sleep to cholesterol, and, most recently, muscle regeneration.
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The research team also discovered that SR8278 increased lean mass and muscle function and decreased muscle fibrosis and muscle protein degradation in mice.
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Source-IANS