About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Microbubbles may Serve as Oxygen Suppliers in Cardiac Arrest

by Chrisy Ngilneii on January 24, 2018 at 3:30 PM
Font : A-A+

Microbubbles may Serve as Oxygen Suppliers in Cardiac Arrest

Air-filled microbubbles that could be used as an intravenous oxygen carrier to increase the survival rate of asphyxial cardiac arrest patients have been developed by a combined research at the Boston Children's Hospital and Harvard University.

Because these microbubbles rapidly dissolve in blood, the risk of embolism is minimal.

Advertisement


Severe oxygen deficiency eventually leads to cardiac arrest. If the blood's oxygen content cannot be rapidly re-established, the patient may die within minutes.

Whether it results from a swimming accident, a piece of food in the trachea, an asthma attack, pertussis, or heart failure: In the United States alone, about 100,000 in-hospital patients die every year from cardiac arrest resulting from asphyxia. The microbubbles developed by the research working with Brian D. Polizzotti and John N. Kheir at Boston Children's Hospital and Harvard University (Boston, Massachusetts, USA) may be able to save many, because they give doctors some time to remedy the cause of the oxygen deprivation or to perform a tracheotomy to re-establish air flow.
Advertisement

The idea of using microbubbles as a way to carry substances, such as drugs or contrast agents, is not new. However, their intravenous injection always involved a high risk of life-threatening pulmonary embolism because they remained in the blood for too long. Other problems included low stability, components that couldn't be broken down, and poor control over morphology and size.

The new microbubbles do not have these disadvantages
. Their success is due to a special production method involving the nanoprecipitation of biocompatible polymers at the interface between air and liquid. The starting material is dextran, a branched polymer made of glucose units. Functional groups such as acids are attached to give the polymer surface-active properties. When the polymer is dissolved in an organic solvent and water, in which it is not soluble, is added, it forms micelles. Homogenization with air forms a foam containing air bubbles surrounded by micelles. When more water is added, more and more micelles come together. These form solid nanoaggregates that form a shell around the air bubble.

When these microbubbles are added to blood, its pH value makes the acid groups form charged carboxylate groups. This allows water to penetrate the shell and release the oxygen. The electrostatic repulsion between the charges causes the shells to fall apart and the components dissolve completely.

The researchers blocked the airways of rodents to induce asphyxial cardiac arrest. After 10 minutes, they removed the blockage to simulate a doctor re-stablishing the airway. While all of the animals in the control group died, the rapid and repeated injection of the microbubbles during cardiac arrest saved all animals. There were no signs of embolism. Comparison with other oxygen carriers also demonstrated that the self-disrupting microbubbles were the only method by which the rodents were able to receive large amounts of oxygen, up to 12 mL without complications.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Chest Pain Palpitations And Arrhythmias Cardiac Catheterization Statins Cardiomyopathy Therapeutic Hypothermia Implantable Cardioverter Defibrillator Cardiac Arrest 

Recommended Reading
Cardiac Arrest
Cardiac arrest occurs when the heart stops beating abruptly due to an electrical malfunction. Blood ...
Cardiac Ablation
Cardiac Ablation is a minimally invasive heart procedure, which involves identifying and scarring .....
Congestive Heart Failure
Congestive heart failure (CHF) is a condition in which the heart fails to work adequately as a pump ...
Cardiac Rehabilitation
Do you know how cardiac rehabilitation could help cardiac patients and why it is so effective? Read ...
Cardiac Catheterization
Cardiac catheterization is a radiological procedure for both diagnosis and treatment of heart condit...
Cardiomyopathy
Cardiomyopathy weakens the heart muscles and the heart loses strength to pump blood throughout the b...
Chest Pain
Ask any one who has experienced intense chest pain and they will vouch for the fact that it was the ...
Implantable Cardioverter Defibrillator
An Implantable Cardioverter Defibrillator is an implantable cardiac device which defibrillates the h...
Palpitations And Arrhythmias
Palpitations are unpleasant sensation of one’s own heartbeat....
Statins
Statins are new wonder drugs that are proving to be efficacious, not merely in relieving symptoms bu...
Therapeutic Hypothermia
Therapeutic hypothermia involves the lowering of the body temperature to 350C or less to limit brain...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use