![Mapping Group Bacteria Communication to Explain Antibiotic Resistance Mapping Group Bacteria Communication to Explain Antibiotic Resistance](https://images.medindia.net/health-images/1200_1000/treatment-for-antibiotic-resistant-bacteria.jpg)
‘An exploration of antibiotic resistance highlights how communities of bacteria, like the pathogen P. aeruginosa, causing pneumonia, sepsis and other infections respond to antibiotics.’
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"There is a general lack of understanding about how communities of bacteria, like the opportunistic pathogen P. aeruginosa, respond to antibiotics," said Nydia Morales-Soto, senior research scientist in civil and environmental engineering and earth sciences (CEEES) at the University of Notre Dame and lead author of the paper. "Most of what we know is from studies about stationary biofilm communities, whereas less is known about the process beforehand when bacteria are colonizing, spreading and growing. In this study, our research team specifically reviewed the behavior of bacteria during this period and what that may mean for antibiotic resistance." ![twitter](https://images.medindia.net/icons/news/social/twitter.png)
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The reported behavior was caused by tobramycin, an antibiotic commonly used in clinical settings, and resulted in a dual signal response. As this antibiotic was applied to a colony of P. aeruginosa, the bacteria produced a signal to a localized area of the colony -- a Pseudomonas quinolone signal (PQS) that is known to occur -- as well as a second, community-wide response, known as the alkyl hydroxyquinoline (AQNO).
The team mapped production of each response spatially, and determined that P. aeruginosa is capable of producing PQS in small pockets at significantly higher concentrations than previously recorded. These findings helped secure the paper's selection as a JBC "Editor's Pick," a recognition only given to the top 2 percent of manuscripts published in the journal for a given year.
The study showed that PQS and AQNO are independently regulated responses that are intentionally communicating different messages. Additionally, this means the bacteria type may have some capability to protect the colony from some external toxins while the bacteria are still in a colonizing phase.
"Although the AQNO response identified in the paper is a stress-dependent behavior, it is such a new chemical message that it has not yet been definitively labeled as a signal. Although, based on our findings, we believe it is," said Joshua Shrout, associate professor of CEEES and concurrent associate professor of biological sciences at the University of Notre Dame and co-author of the paper. "Regardless, this work opens a new window into understanding P. aeruginosa behavior and potentially how this bacterium promotes tolerance to antibiotics."
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Source-Eurekalert