About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Link Between Muscle Damage and Cerebral Malaria Identified

by Sheela Philomena on April 19, 2014 at 8:40 AM
Font : A-A+

 Link Between Muscle Damage and Cerebral Malaria Identified

New study conducted by scientists finds an association between muscle damage and cerebral malaria. Scientists compared proteins in the blood of uninfected children with those in the blood of infected ones, and also proteins in blood from children with different severe malaria syndromes with proteins in blood from uncomplicated cases.

The researchers analyzed over 1000 proteins in more than 700 children. To make the study more rigorous, the samples were divided into "discovery" and "verification" sets, and only associations that were found in both were reported. There were 41 proteins that could distinguish between malaria patients and uninfected children from the same community. Most of these were components of the inflammatory response.

Advertisement

The researchers also found proteins that were specific to the two most deadly complicated malaria syndromes in children, namely severe malaria anemia and cerebral malaria. For both, combinations of proteins, so-called "signatures", could identify the specific syndrome with high accuracy.

For cerebral malaria, the researchers found that a group of muscle-specific proteins was present in the children's blood, suggesting that muscle cells are damaged. At least some of that damage might be associated with coma, which occurs in cerebral malaria but also in other diseases like meningitis.
Advertisement

The researchers conclude that their study could "provide key elements toward the discovery of distinct mechanisms in the human response to malaria infection between the two most fatal syndromes of childhood malaria" and that muscle-specific proteins in plasma might be "potential indicators of cerebral malaria".

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Health Benefits of Sea Buckthorn
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Malaria-water Malaria Mosquito Diseases Fever Compartment Syndrome Malaria - Protection Strategies 

Recommended Reading
Malaria
Malaria is caused by a parasite that enters blood through the bite of an infected mosquito. It is .....
McMaster Researchers Discover That Muscle Damage Is Illustrated By A Specific Protein
A protein that is only detectable after muscle damage, and it may serve as a way to measure injury, ...
Muscle Damage Caused by Genetic Disease can be Treated
Researchers from the University of Edinburgh in Scotland claim that it is possible to treat the ......
Cycling Doping Drug, EPO, Could Reduce Cerebral Malaria-Related Deaths
EPO- the doping drug known from professional cycling- can significantly reduce cerebral malaria ......
Compartment Syndrome
Compartment syndrome can be a potentially life-threatening condition, which involves increased press...
Fever
Fever or Pyrexia is an elevation in normal body temperature. Causes of fever include infections, inj...
Malaria - Protection Strategies
Malaria is a dangerous disease with lethal consequences that requires protective measures for preven...
Mosquito Diseases
Mosquito-borne diseases, like malaria, filaria, dengue, etc are common in places conducive of mosqu...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use