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Human Skin Cells Used to Create Motor Neurons of Lou Gehrig's Disease

by Rajashri on August 4, 2008 at 3:06 PM
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 Human Skin Cells Used to Create Motor Neurons of Lou Gehrig's Disease

Disease-specific stem cells may be derived from an individual patient, a collaborative study carried out by researchers from the Harvard Stem Cell Institute (HSCI) and Columbia University for Project ALS, has shown.

Researchers have demonstrated that pluripotent stem cells derived from a patient with ALS (amyotrophic lateral sclerosis) can then be differentiated into motor neurons-the brain cells which are destroyed by ALS.

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In this study, led by Kevin Eggan, of the Harvard Stem Cell Institute, skin cells taken from a patient with a familial form of ALS were induced to become pluripotent stem cells.

Later, they differentiated the pluripotent cells into motor neurons and glia (support cells in the brain) that featured an ALS genotype.

"This is a seminal discovery. The ability to derive ALS motor neurons through a simple skin biopsy opens the doors to improved drug discovery. For the first time, researchers will be able to look at ALS cells under a microscope and see why they die. If we can figure out how a person's motor neurons die, we will figure out how to save motor neurons," said Valerie Estess, director of research for Project ALS.
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Project ALS, started in 1999, recruited leading scientists and clinicians to define the potential role of stem cells in understanding and treating ALS, the fatal neurodegenerative disease, also known as Lou Gehrig's disease. Project A.L.S.-funded scientists began by transplanting stem cells directly into mice with ALS, with limited success.

More recent experiments have shown that stem cells may be more valuable as tools to understand the disease process and create mini-representations of disease-or assays--for the purpose of drug screening.

"For the first time, we have the opportunity to examine cellular and molecular defects in motor neurons and glial cells derived from patients with ALS. And we can now begin drug screens on disease-specific classes of human motor neurons. Through the work of the Jenifer Estess Laboratory for Stem Cell Research we now can glimpse the new age of ALS research, an age of progress and promise," said Thomas Jessell, a Howard Hughes Investigator at Columbia University, and Project A.L.S. advisor.

"It has been a privilege to collaborate with Kevin Eggan and his team and to contribute to this critical step forward. We will continue to work hand-in-hand with Harvard researchers and Project A.L.S. to exploit the potential of these cells for drug screening," said Christopher Henderson, co-author on the paper

The results of the team's study appear in today's online issue of Science.

Source: ANI
RAS/L
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