HPV Comes as a Boon for African Americans Who Have Throat Cancer

A new study suggests that human papillomavirus (HPV) comes as a boon for African Americans who have throat cancer.

A new study conducted by researchers at Henry Ford Hospital suggests that human papillomavirus (HPV) comes as a boon for African Americans who have throat cancer even though the presence of the virus increases the risk of certain head and neck cancers.

The study shows that African Americans who are HPV-positive have better outcomes than African Americans without HPV.

Cancer of Larynx (Throat Cancer)-Risk Factors-Symptoms-Diagnosis-Treatment
Laryngeal cancer is also called cancer of the larynx or throat cancer or laryngeal carcinoma. It usually affects men over the age of 55 years.

African Americans who are HPV-negative also fared worse than Caucasians both with and without HPV present in oropharyngeal cancer, a cancer that affects part of the throat, the base of the tongue, the tonsils, the soft palate (back of the mouth), and the walls of the pharynx (throat).

The study is published online in the journal Clinical Cancer Research.

"This study adds to the mounting evidence of HPV as a racially-linked sexual behavior lifestyle risk factor impacting survival outcomes for both African American and Caucasian patients with oropharyngeal cancer," says lead author Maria J. Worsham, Ph.D., director of research in the Department of Otolaryngology-Head & Neck Surgery at Henry Ford.

Sore Throat - Symptom Evaluation
Sore throat is a common symptom that usually affects people during a weather change. It is often caused by a viral infection.

The American Cancer Society estimates about 36,000 people in the U.S. will get oral cavity and oropharyngeal cancers in 2013; an estimated 6,850 people will die of these cancers. These cancers are more than twice as common in men as in women. They are about equally common in blacks and in whites.

To compare survival outcomes in HPV-positive and HPV-negative African Americans with oropharyngeal cancer, Dr. Worsham and her team conducted a retrospective study of 118 patients.

Cough - Symptom Evaluation - Frequently Asked Questions
Cough is a symptom of a condition usually affecting the respiratory tract. It may be acute or chronic, wet or dry. The type of cough can help the physician diagnose the underlying condition.

Among the study group, 67 are HPV-negative and 51 are HPV-positive. Forty-two percent of those in the study are African American.

The study found that:

African Americans are less likely to be HPV positive
Those older than 50 are less likely to be HPV positive
Those with late-stage oropharyngeal cancer are more likely to be unmarried and more likely to be HPV positive
HPV negative patients had 2.7 times the risk of death as HPV positive patients
The HPV race groups differed with significantly poorer survival for HPV negative African Americans versus HPV positive African Americans, HPV positive Caucasians and HPV negative Caucasians

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Overall, the study finds HPV has a substantial impact on overall survival in African Americans with oropharyngeal cancer

Source-Eurekalert