HIV Persists in Brain and Spinal Cord Despite Successful Viral Suppression

by Mary Selvaraj on  July 16, 2019 at 11:43 AM AIDS/HIV News
RSS Email Print This Page Comment bookmark
Font : A-A+

HIV persists in the brain and the spinal cord of HIV infected individuals, although there is successful viral suppression in the immune system. These individuals hence exhibit cognitive decline.
HIV Persists in Brain and Spinal Cord Despite Successful Viral Suppression
HIV Persists in Brain and Spinal Cord Despite Successful Viral Suppression

HIV-positive patients are living longer, healthier lives thanks to combination antiretroviral therapy (cART), which prevents the virus from replicating and infecting additional cells. However, HIV's ability to persist in the body despite ongoing cART treatment remains a major obstacle to curing patients. Now, clinical trial results published in the Journal of Clinical Investigation show that HIV can be detected in the central nervous system of patients undergoing long-term cART, and its presence is linked to poor performance on cognitive tests.

Show Full Article


While it was known that cART cannot completely prevent HIV-associated neurological dysfunction, Serena Spudich (Yale University School of Medicine) and colleagues' study appears to be the first to detect the virus in the cerebrospinal fluid (CSF) of patients on long-term cART. Their discovery indicates that HIV can persist in the brain and spinal cord despite years of successful viral suppression. Importantly, Spudich et al. linked the presence of HIV in CSF with poorer performance on a series of cognitive tests, concluding that the brain and spinal cord remain vulnerable to the virus even when the immune system is spared.

In the accompanying commentary, David Clifford explains how Spudich et al.'s findings highlight the need to address viral mechanisms of cognitive decline in cART-treated patients.



Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Recommended Reading

More News on:

Oral Health And AIDS Parkinsons Disease AIDS/HIV AIDS/HIV - Epidemiology AIDS/HIV - Clinical Features AIDS/HIV - Health Education AIDS/HIV - Prevention And Transmission AIDS / HIV - Treatment AIDS/HIV- Lab Tests and Faqs Parkinsons Disease Surgical Treatment 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive