About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

High Nicotine, Carcinogens Found in Smokeless Tobacco Users

by Bidita Debnath on November 22, 2015 at 12:09 AM
Font : A-A+

 High Nicotine, Carcinogens Found in Smokeless Tobacco Users

Adults who used only smokeless tobacco products in U.S. had higher levels of biomarkers of exposure to nicotine and a cancer-causing toxicant -- the tobacco-specific nitrosamine NNK -- compared with those who used only cigarettes.

Journal in Which the Study was Published: Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research

Advertisement


Author: Brian Rostron, PhD, an epidemiologist in the Center for Tobacco Products at the U.S. Food and Drug Administration (FDA).

Background: Even though smokeless tobacco is used less than cigarettes, it continues to be used among several population groups, particularly men and young people, which is a cause for concern because it has been found to have several adverse health effects and identified as a cause of cancer, explained Rostron. "Previous small studies have found high levels of toxic constituents including carcinogens [cancer-causing agents] in smokeless tobacco users, but analyses of nationally representative data have been generally lacking to date," he said.
Advertisement

How the Study Was Conducted: Rostron and colleagues analyzed data on biomarkers of exposure to seven tobacco constituents, including nicotine and tobacco-specific nitrosamine, available from 23,684 adults who participated in NHANES [National Health and Nutrition and Examination Survey] from 1999 to 2012. Participant-reported cigarette and smokeless tobacco use was used to categorize individuals into four groups. There were 16,313 nontobacco users, 488 exclusive smokeless tobacco users, 6,791 exclusive cigarette smokers, and 92 dual cigarette and smokeless tobacco users.

Results: The geometric mean serum level of cotinine, the biomarker of nicotine exposure, was higher in exclusive smokeless tobacco users compared with exclusive cigarette smokers: 178.9 nanograms per milliliter (ng/ml) versus 130.6 ng/ml. The geometric mean urine level of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), the biomarker of NNK exposure, was also higher in exclusive smokeless tobacco users compared with exclusive cigarette smokers: 583.0 picograms per milligram (pg/mg) of creatinine versus 217.6 pg/mg of creatinine.

Author Comment: Rostron said, "Our analysis of data from NHANES, a large, nationally representative study of U.S. health behaviors and outcomes, generated results consistent with those from previous smaller studies. Levels of biomarkers of exposure to nicotine and the cancer-causing tobacco constituent NNK were higher among exclusive smokeless tobacco users than exclusive cigarette smokers. This continues to put smokeless tobacco users at risk for adverse health effects, including cancer."

"Our findings demonstrate the need for continuing study of the toxic constituents of smokeless tobacco as well as their health effects on the individuals who use them," he added. "This is why the FDA and CDC [Centers for Disease Control and Prevention] are continuing to analyze and monitor biomarker levels among tobacco users and why the FDA and NIH [National Institutes of Health] are collaborating on the Population Assessment of Tobacco and Health (PATH) Study, a large longitudinal study in which biospecimens such as blood and urine have been collected."

Study Limitations: Rostron explained that although the current study uses the best available data, the nature of the data collected in NHANES is a limitation to the study. For example, because NHANES is a general health survey, there is no detailed information on the type of smokeless tobacco product used; there is no information on the quantity of the smokeless tobacco product used; and there is no information on duration or former use of smokeless tobacco products. He concluded that PATH Study data will allow for more specific analyses of tobacco use and harm.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Heart Day in 2022- Use Heart for Every Heart
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
H1N1 Influenza Prevention in Children: What Parents Need to Know
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Health Hazards of Smoking Smoking And Cancer Smoking And Tobacco 

Most Popular on Medindia

How to Reduce School Bag Weight - Simple Tips Diaphragmatic Hernia Calculate Ideal Weight for Infants Drug Interaction Checker The Essence of Yoga Vent Forte (Theophylline) Accident and Trauma Care Indian Medical Journals Nutam (400mg) (Piracetam) Blood Pressure Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

High Nicotine, Carcinogens Found in Smokeless Tobacco Users Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests