APOE4 is associated with a reduction in the brain's ability to dynamically modulate in response to cognitive challenge.
Genetics of Alzheimer’s disease
There are numerous genes that have been discovered that are associated with Alzheimer’s disease and indicate increased risk, aiding genetic counseling and better care.
There are numerous genes that have been discovered that are associated with Alzheimer’s disease and indicate increased risk, aiding genetic counseling and better care.
‘Healthy adults carrying the gene APOE4, the strongest known genetic risk factor for Alzheimer's disease may struggle to adapt their brain activity to increasing cognitive demands as they get older.’
This age-related effect, which was not observed in people without the risk factor, suggests that interventions targeting cognitive decline in at-risk populations may need to begin many years before any symptoms of the disease emerge in order to be effective. Karen Rodrigue and colleagues assessed the performance of 31 adults (ages 20-86) with APOE4 on a distance judgment task at different levels of difficulty while measuring their brain activity.
Although these at-risk participants showed similar adjustment in brain activity to the difficulty of the task as non-APOE4 carrying adults of the same age, sex, and education level, this ability declined with increasing age in the individuals with APOE4.
Alzheimer’s disease - Causes, Symptoms, Diagnosis, Stages, Types, Prevention, Prognosis & Treatment
Alzheimer's disease is a progressive neurodegenerative disease affecting memory and thinking and making the person increasingly dependent on others.
Alzheimer's disease is a progressive neurodegenerative disease affecting memory and thinking and making the person increasingly dependent on others.
Source-Eurekalert
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most common lifestyle habits that cause chronic diseases such as obesity, hypertension, diabetes mellitus, cancer and cardiovascular disease.
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most common lifestyle habits that cause chronic diseases such as obesity, hypertension, diabetes mellitus, cancer and cardiovascular disease.
Diet and Alzheimer's Disease
Alzheimer's begins with forgetfulness, but over time affects speech and coordination along with drastic behavioral changes. The right diet may lower your risk by 40%. So isn't a diet change worth it?
Alzheimer's begins with forgetfulness, but over time affects speech and coordination along with drastic behavioral changes. The right diet may lower your risk by 40%. So isn't a diet change worth it?
