Traumatic brain injury (TBI) refers to a brain injury caused by a blow to the head or a violent shaking of the head and body. In patients who suffered acute orthopedic injuries, two proposed
biomarkers for mild traumatic brain injury (mTBI) were not able to
distinguish between patients who did or did not have mTBI.
Relying on elevated levels of the proteins GFAP and UCH-L1 to identify patients with mTBI could lead to false-positive diagnoses and unnecessary brain imaging, as reported in an article in Journal of Neurotrauma, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.
Relying on elevated levels of the proteins GFAP and UCH-L1 to identify patients with mTBI could lead to false-positive diagnoses and unnecessary brain imaging, as reported in an article in Journal of Neurotrauma, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.
Jussi Posti and coauthors from Turku University Hospital and University of Turku (Finland), VTT Technical Research Center of Finland (Tampere), and University of Cambridge, Addenbrooke's Hospital (U.K.), measured the levels of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) in patients at several time points after acute orthopedic injuries.
‘Two proposed biomarkers for mild traumatic brain injury (mTBI), GFAP and UCH-L1, were not able to identify patients with mTBI. This could lead to false-positive diagnoses and unnecessary brain imaging.’
"This study represents another important contribution to the field of biomarker discovery within the context of mild traumatic brain injury," says John T. Povlishock, Editor-in-Chief of Journal of Neurotrauma.
"Although as noted by the authors, this study used platforms and assays different from previous reports in the literature, the fundamental fact remains that this study's findings emphasize the need for increased vigilance when using GFAP and UCH-L-1 as potential biomarkers of mild traumatic brain injury in a patient population that has sustained concomitant orthopedic injury."
Source: Eurekalert
- << Exposure to Air Pollution Linked to Risk of Developing Type...
- Drinking Alcohol With Opioids Increases the Risk of Respira... >>
Recommended Reading
Sleep Helps Memory Consolidation Even After Mild Traumatic Brain Injury (TBI)
People with a mild TBI had a greater recall in a word memorization task after they had slept compared to those who were kept awake for the same period.
Mild Traumatic Brain Injury Reduces Quality of Parent-Child Relationships
Mild traumatic brain injury or concussion in children between the ages of 0 to 5 years can reduce the development of new abilities like communication skills.
Research: Current Models for Predicting Outcomes After Mild Traumatic Brain Injury Perform Poorly
Risk identification is essential for the 5-15% of patients with mild traumatic brain injury (mTBI) who will have lingering problems.
Specialized MRI Technique Helps Physicians Predict Outcomes Following Mild Traumatic Brain Injury
Diffusion Tensor Imaging (DTI) is a specialized magnetic resonance imaging (MRI) technique that detects microstructural changes in brain tissue.
Aphasia
Aphasia is a condition where the patient has a language disorder. The patient has problems with comprehension, expression, repetition, reading and writing.
Ataxia
Ataxia affects coordination. Gait becomes unstable and the patient loses balance. The cerebellum or its inputs and/or outputs are affected.
Head Injury
Head injury or traumatic brain injury is a leading cause of disability among children and young adults that leads to varying degrees of physical and mental stability. Fortunately, it is also one of the preventable brain disorder.
Language Areas in The Brain
The mechanism of how human brain processes the language to express and comprehend the verbal, written, gestures and symbols is still a mystery.
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. Symptoms of Parkinson’s disease are correctable to an extent.
