Traumatic brain injury (TBI) refers to a brain injury caused by a blow to the head or a violent shaking of the head and body. In patients who suffered acute orthopedic injuries, two proposed
biomarkers for mild traumatic brain injury (mTBI) were not able to
distinguish between patients who did or did not have mTBI.
Relying on
elevated levels of the proteins GFAP and UCH-L1 to identify patients
with mTBI could lead to false-positive diagnoses and unnecessary brain
imaging, as reported in an article in Journal of Neurotrauma, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.
Sleep Helps Memory Consolidation Even After Mild Traumatic Brain Injury (TBI)
People with a mild TBI had a greater recall in a word memorization task after they had slept compared to those who were kept awake for the same period.
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‘Two proposed biomarkers for mild traumatic brain injury (mTBI), GFAP and UCH-L1, were not able to identify patients with mTBI. This could lead to false-positive diagnoses and unnecessary brain imaging.’
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Jussi Posti and coauthors from Turku University Hospital and University of Turku (Finland), VTT Technical Research Center of Finland (Tampere), and University of Cambridge, Addenbrooke's Hospital (U.K.), measured the levels of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) in patients at several time points after acute orthopedic injuries.
The researchers compared the
levels to those in patients with computed tomography (CT)-negative mTBI.
They report the results in the article entitled "Glial Fibrillary
Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Are Not Specific
Biomarkers for Mild CT-Negative Traumatic Brain Injury."
![Mild Traumatic Brain Injury Reduces Quality of Parent-Child Relationships]( "Mild Traumatic Brain Injury Reduces Quality of Parent-Child Relationships")
Mild traumatic brain injury or concussion in children between the ages of 0 to 5 years can reduce the development of new abilities like communication skills.
"This study represents another important contribution to the field of biomarker discovery within the context of mild traumatic brain injury," says John T. Povlishock, Editor-in-Chief of Journal of Neurotrauma.
"Although as noted by the authors, this study used platforms and assays different from previous reports in the literature, the fundamental fact remains that this study's findings emphasize the need for increased vigilance when using GFAP and UCH-L-1 as potential biomarkers of mild traumatic brain injury in a patient population that has sustained concomitant orthopedic injury."
Source: Eurekalert
Mild Traumatic Brain Injury Reduces Quality of Parent-Child Relationships
Mild traumatic brain injury or concussion in children between the ages of 0 to 5 years can reduce the development of new abilities like communication skills.
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"This study represents another important contribution to the field of biomarker discovery within the context of mild traumatic brain injury," says John T. Povlishock, Editor-in-Chief of Journal of Neurotrauma.
"Although as noted by the authors, this study used platforms and assays different from previous reports in the literature, the fundamental fact remains that this study's findings emphasize the need for increased vigilance when using GFAP and UCH-L-1 as potential biomarkers of mild traumatic brain injury in a patient population that has sustained concomitant orthopedic injury."
Source: Eurekalert
Research: Current Models for Predicting Outcomes After Mild Traumatic Brain Injury Perform Poorly
Risk identification is essential for the 5-15% of patients with mild traumatic brain injury (mTBI) who will have lingering problems.
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 Specialized MRI Technique Helps Physicians Predict Outcomes Following Mild Traumatic Brain InjuryDiffusion Tensor Imaging (DTI) is a specialized magnetic resonance imaging (MRI) technique that detects microstructural changes in brain tissue. | Advertisement
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