About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Genetic Similarities of Osteosarcoma Between Dogs and Children Revealed

by Colleen Fleiss on July 26, 2019 at 3:19 AM
Font : A-A+

Genetic Similarities of Osteosarcoma Between Dogs and Children Revealed

Osteosarcoma, a bone cancer was found to be genetically similar in dogs and human children, according to the results of a study published today by Tufts University and the Translational Genomics Research Institute (TGen), an affiliate of City of Hope.

The findings could help break the logjam in the treatment of this deadly disease, which hasn't seen a significant medical breakthrough in nearly three decades.

Advertisement


"While osteosarcoma (OS) is rare in children, it is all too common in many dog breeds, which makes it a prime candidate for the kind of comparative cancer biology studies that could enhance drug development for both children and our canine friends," said Will Hendricks, Ph.D., an Assistant Professor in TGen's Integrated Cancer Genomics Division, and one of the study's senior authors.

Using multiple molecular-level testing platforms, TGen and Tufts researchers sequenced the genomes of 59 dogs, finding that canine OS shares many of the genomic features of human OS, including low mutation rates, structural complexity, altered cellular pathways, and unique genetic features of metastatic tumors that spread to other parts of the body.
Advertisement

Study results appeared today in the Nature journal, Communications Biology.

"These findings set the stage for understanding OS development in dogs and humans, and establish genomic contexts for future comparative analyses," said Cheryl A. London, DVM, Ph.D., the Anne Engen and Dusty Professor in Comparative Oncology at Cummings School of Veterinary Medicine at Tufts University, and the study's other senior author.

The study also identified new features of canine OS, including recurrent and potentially cancer-causing mutations in two genes, SETD2 and DMD. The study suggests that these findings merit further exploration.

OS is an aggressive disease and the most commonly-diagnosed primary bone tumor in dogs and children. Though a relatively rare cancer in humans -- with fewer than 1,000 cases each year -- OS strikes more than 25,000 dogs annually.

Although surgery and chemotherapy can extend survival, about 30 percent of pediatric OS patients die from metastatic tumors within 5 years. The cancer moves much faster in dogs, with more than 90 percent succumbing to metastatic disease within 2 years.

"The genetic similarity between dogs and humans provides a unique opportunity and a comparative model that will enable the development of new therapies within a compressed timeline," said Heather L. Gardner, DVM, a Ph.D. candidate in Tufts' Sackler School of Graduate Biomedical Sciences, and the study's lead author.

Jeffrey Trent, Ph.D., FACMG, TGen President and Research Director, and a contributing author, said the comparative oncology approach is vital to the rapid development of new treatments for people and pets that need help today.

"More importantly, it provides an opportunity to develop therapies that make a difference in the lives of children and pets," said Dr. Trent, who has been a proponent of comparative oncology for more than a decade.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Insulin Resistance Doubles the Risk of Major Depressive Disorder
Emotional Healing
Psychosis Risk Related to Cat Parasite
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Height and Weight-Kids Genetics and Stem Cells Osteosarcoma Christianson Syndrome Soft Tissue Sarcoma 

Recommended Reading
Bone Cancer
Find the facts of bone cancer including types of bone cancer, symptoms, causes, treatment, ......
Quiz on Bone Cancer
Bone cancer may arise primarily from a bone or may spread from other organs to the bone. See how ......
Osteosarcoma
Osteosarcoma is a primary cancer of the bone which targets adolescents most commonly and mainly ......
Molecular Imaging Technique Spots Lung Nodules in Osteosarcoma
Lung nodules can be identified using near-infrared imaging, which will enable the surgeons to ......
Christianson Syndrome
Christianson syndrome is a condition that occurs due to mutations (abnormal changes) in the gene SLC...
Soft Tissue Sarcoma
Soft tissue sarcoma is a rare cancer of connective tissue that can affect soft tissues such as fat, ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use