Could Better Screening Help Predict Sudden Cardiac Death?

In young adults with hypertrophic cardiomyopathy (HCM) expanding cardiac screening beyond competitive athletes could aid in the prevention of sudden cardiac death (SCD).

What is Hypertrophic Cardiomyopathy

HCM is a genetic cardiovascular disease believed to affect one in every 500 individuals in the general population. While sudden death due to HCM is rare, it is still a major cause of natural death in the young. Identifying at-risk patients can reduce the risk of SCD in young individuals with HCM, for example through exercise restriction and drug therapies. Implantable cardioverter defibrillators (ICDs) can also prevent deaths and improve quality of life. For instance, after suffering an on-field cardiac arrest last year, Danish footballer Christian Eriksen was able to return to playing eight months later with an ICD. In the new study, the researchers analyzed all cases of SCD with HCM between 2000 and 2010 in Sweden among individuals under age 35, along with controls. They characterized the clinical symptoms, medical history, family history and ECG findings before the occurrence of SCD using data from national registries, autopsy reports, medical records, and interviews with relatives post-mortem.

Sudden Cardiac Death in Young Generation

Among the 38 SCD cases identified, which included 31 males and 7 females, 71% presented with possible cardiac symptoms, including chest pain and palpitations, before death, and 69% received medical care in the 180 days before death (compared to just 21% of controls receiving medical care in that time period). 39% had a known cardiac disorder prior to death and 50% had a positive family history of heart disease. In total, 28 individuals underwent ECG evaluation at some point during their lifetime. Of these, 23 (82%) had ECG findings that were considered abnormal, but the overall number of abnormal ECG-recordings is around 60% when looking at all the cases. The authors conclude that it may be possible to predict, and prevent, SCD in young individuals with HCM. ECG screening, for instance, could be expanded beyond competitive athletes and a routine school screening program could ensure equal detection across males and females. The authors add: “The majority of young people dying from sudden cardiac death due to HCM present with one or more abnormalities that may be recognized during cardiac screening.”

Source-Eurekalert