About My Health Careers Internship MedBlogs Contact us

Cholesterol Drug Simvastatin Associated With Sleep Disruptions

by Ann Samuel on November 8, 2007 at 4:22 PM
Font : A-A+

Cholesterol Drug Simvastatin Associated With Sleep Disruptions

New research finds that the cholesterol- lowering drug, simvastatin, can affect the sleeping patterns of some patients.

The study, presented at the American Heart Association's Scientific Sessions 2007, involved 1,016 healthy adult men and women.


The volunteers were tested for six months in a randomized, double-blind, placebo-controlled trial using simvastatin, given at 20 milligrams (mg), pravastatin at 40 mg, or a placebo. The research did not include patients with heart disease or diabetes due to concerns about assigning these people to placebos.

The researchers assessed the outcomes with the Leeds sleep scale, a visual analog scale of sleep quality, as well as a rated the scale of sleep problems. Both scales were measured before and during treatment.

The study compared two types of cholesterol-lowering drugs called statins — simvastatin, which was lipophilic (soluble in fats), and pravastatin, which was hydrophilic (soluble in water).

They found that simvastatin affected patients' sleep patterns. This the researchers say, is because simvastatin is fat soluble and can thus more readily penetrate cell membranes and cross the blood brain barrier into the brain. The brain controls sleep, and many of the brain's nerve cells are wrapped in a fatty insulating sheath called myelin.

"The results showed that simvastain use was associated with significantly worse sleep quality. A significantly greater number of individuals taking simvastatin reported sleep problems than those taking either pravastain or the placebo," said Beatrice Golomb, M.D., lead author of the study and an associate professor of medicine and family and preventive medicine at the University of California at San Diego School of Medicine.

"The findings are significant because sleep problems can affect quality of life and may have adverse health consequences, such as promoting weight gain and insulin resistance.

"Several small studies were done early on, including those focused on lipophilic versus hydrophilic statins. "Most (researchers) didn't see a difference in sleep, but they had short durations of follow-up and enrolled just a handful of people — often fewer than 20, which was not enough to see a difference unless it was very large. "One of these studies did report a significant difference between pravastatin and simvastatin. But without more and bigger studies, an effect was not considered to be established. "Those who reported developing much worse sleep on study medication also showed a significant adverse change in aggression scores compared to others, we should also point out that although the average effect on sleep was detrimental on simvastatin, this does not mean that everyone on simvastatin will experience worse sleep," said Golomb.

The research was funded by the National Heart, Lung, and Blood Institute of the National Institutes of Health.

Source: ANI

News A-Z
News Category
What's New on Medindia
Western Diet may Augment the Risk of Autoimmune Diseases
Black Tea Protects against Blood Pressure and Heart Diseases
Green Mediterranean Diet may Help Repair Age-Related Brain Damages
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cholesterol High Cholesterol Drug Toxicity Snoring Sleep Disorder : Restless Legs Syndrome Sleep Disorder: Sleepwalking Periodic Limb Movement Disorder REM Behavior Disorder Sleep Disturbances In Women Sleep 

Recommended Reading
New Combination Pill may Improve Multiple Cholesterol Disorders
A new study has found that patients treated with a new investigational combination pill show ......
Simvastatin - First Among Unequals
According to a study by American researchers, not all statins are alike in their ability to reduce ....
Cholesterol is produced by the body (liver) and is essential for normal body functioning....
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
High Cholesterol
High cholesterol level in blood are a risk for heart disease and stroke. They get deposited in the w...
Periodic Limb Movement Disorder
Periodic limb movement disorder (PLMD) is a sleep disorder which causes repetitive cramping or jerki...
REM Behavior Disorder
REM Behavior Disorder (RBD) is a sleep disorder in which the person acts out dramatic or violent dre...
Sleep is a behavioral state of restricted physical activity. It is controlled by our internal biolo...
Sleep Disorder : Restless Legs Syndrome
Restless legs syndrome (RLS) causes - An urge to move, usually due to uncomfortable sensations that...
Sleep Disorder: Sleepwalking
Sleepwalking or “Somnambulism,” is a type of parasomnia and has medico-legal implications...
Sleep Disturbances In Women
The physical, emotional and hormonal changes that occur in women during puberty, menstrual cycle, pr...
Turbulent airflow causes tissues of the nose and throat to vibrate and the noise produced by these v...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)