A recent study says that drugs already approved for clinical use across a variety of therapeutic categories can be screened to identify effective agents for thyroid cancer. The study has been accepted for publication in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
These findings could rapidly be implemented into a clinical trial to test how effective the treatment would be.
The discovery of new chemical agents capable of modulating a disease is a long and expensive process. An alternative approach that is just beginning to be explored is the potential repurposing of already established drugs which have been approved for clinical use. The current study examined the newly assembled National Institutes of Health (NIH) Chemical Genomic Center's pharmaceutical collection, which contains 2,816 approved drugs and bioactive compounds and sought to identify agents with an anti-cancer effect in thyroid cancer cell lines.
In this study, researchers used a quantitative high-throughput screening (qHTS) approach to examine the effect of 2,816 clinically approved drugs on thyroid cancer cells. qHTS is a titration-based screening paradigm where compounds are screened at multiple concentrations. By employing this approach, researchers found numerous agents across different therapeutic categories and mode of action that had an anti-cancer effect.
"Clinicians can more readily translate these findings into therapy when the drug characteristics are well-known. The drugs can then be used in developing clinical trials or in some cases for off-label use," said Kebebew. "Furthermore, qHTS could be used for identifying therapeutics not only for cancer, but for many other diseases."