About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Blood Factor Associated With a Leading Cause of Kidney Disease Identified

by Sheela Philomena on November 10, 2012 at 9:32 AM
Font : A-A+

 Blood Factor Associated With a Leading Cause of Kidney Disease Identified

According to a recent study published in the Journal of the American Society of Nephrology, patients with a disease that is a leading cause of kidney failure tend to have increased levels of a particular factor circulating in their blood. The findings suggest that the factor could be used to monitor the disease''s progression as well as patients'' response to different therapies. It might also be a therapeutic target of future treatments for this difficult-to-treat disease.

Focal segmental glomerulosclerosis (FSGS), which is characterized by scarring of the kidneys, is a devastating disease in both children and adults. Most therapies are not effective, and patients often eventually need to undergo a kidney transplant. Research indicates that high blood levels of a factor called soluble urokinase receptor (suPAR)-which is overproduced in FSGS-plays a key role in the development of the disease. At high concentrations, suPAR binds to and damages kidney podocyte cells, leading to poor kidney filtration and protein excretion in the urine, eventually causing kidney failure.

Advertisement

Jochen Reiser, MD, PhD (Rush University Medical Center) and his colleagues evaluated suPAR levels in the blood of 70 adult FSGS patients from North America, 94 pediatric FSGS patients from Europe, and 150 individuals without the disease. They also analyzed suPAR levels after patients were treated with various drugs.

Among the major findings
- 84% and 55% of FSGS patients in the two different cohorts had elevated suPAR levels in their blood, compared with only 6% of individuals without FSGS.
- After treatment with mycophenolate mofetil, an immunosuppressant, patients had significantly reduced suPAR levels in the blood. They also had reduced protein excretion in the urine and a greater likelihood of experiencing remission.
- Treatment with cyclosporine A, another immunosuppressant, did not produce these effects.
Advertisement

The findings suggest that suPAR blood tests might be used to monitor patients'' disease and their response to treatment. Also, "anti-suPAR therapies may help reduce the burden of FSGS," said Dr. Reiser. "Since FSGS can recur after kidney transplantation, suPAR removal may also have relevance in the treatment of post-transplant FSGS," he added.

Study co-authors include Changli Wei, MD, PhD, Howard Trachtman, MD, Jing Li, Chuanhui Dong, PhD, Aaron L. Friedman, MD, Debbie S. Gipson, MD, Frederick Kaskel, MD, PhD, Dagmar-C. Fischer, MD, Jennifer J. Gassman, PhD, June L. McMahan, MD, Milena Radeva, Karsten M. Heil, MD, Agnes Trautmann, MD, Ali Anarat, MD, Sevinc Emre, MD, Gian M. Ghiggeri, MD, PhD, Fatih Ozaltin, MD, Dieter Haffner, MD, and Franz Schaefer, MD.

Source: Newswise
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Monkeypox Outbreak: What it is, How Does it Spread & the Prevention
Seasonal Allergy Medications
How to Choose the Best Eczema-Friendly Moisturizer for Children?
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Thalassemia Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Kidney Disease Kidney Kidney Health Stones in Urinary Tract Renal Tubular Acidosis Diabetic Kidney Disease 

Most Popular on Medindia

Loram (2 mg) (Lorazepam) Vent Forte (Theophylline) The Essence of Yoga Find a Doctor Color Blindness Calculator Diaphragmatic Hernia Turmeric Powder - Health Benefits, Uses & Side Effects Drug - Food Interactions Blood Pressure Calculator Blood - Sugar Chart

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use