![Blocking Protein Action Minimizes Serious Ill Effects of High BP on Heart Blocking Protein Action Minimizes Serious Ill Effects of High BP on Heart](https://images.medindia.net/health-images/1200_1000/BloodPressure-ReducingMedication.jpg )
These include heart muscle enlargement, scar tissue formation and loss of blood vessel growth.
Specifically, the team found that their intervention halted transforming growth factor beta (TGF-beta) secretion at a precise location called cell receptor type 2 in cardiac muscle cells.
Blocking its action in this cell type forestalled pathways for hypertrophy, fibrosis, and angiogenesis by stopping the unbridled TGF-beta signaling, which is typically observed in heart failure, in all other non-muscle types of cells in blood vessels and fibrous tissue.
However, blocking TGF-beta signaling in non-muscle cells did not stop disease progression.
The study is believed to show the first evidence of how TGF-beta is stimulated differently by various cell types in the heart and which resulting pathways promote heart failure, the most common kind of heart disease.
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Source-ANI