Immunosuppression and Risk of Non Hodgkins Lymphoma (NHL)

Immunosuppression and Risk of Non Hodgkins Lymphoma (NHL)

Individuals who are immuno-suppressed e.g. those with AIDS have more risk to develop.


Non Hodgkin's Lymphoma (NHL) than others. They are-

• Those who have undergone an organ transplant, especially those who are in the first year after a transplant.
• Those with certain types of inherited immune deficiency syndromes. The following list of familial immune deficiencies with a predisposition for Lymphomas has been adapted from Chapters 19, 21, 45, and 47 of Magrath's text, The Non-Hodgkin's Lymphomas (1997):
• X-linked severe combined immunodeficiency (SCID).
• Omenn's syndrome.
• Purine nucleoside phosphorylase deficiency.
• Familial immunodeficiency appears to predispose certain families to more than the expected incidence of NHL
• X-linked agammaglobulinemia.
• Ig-A deficiency.

• Common variable immune deficiency.
• X-linked hyper-IgM syndrome.
• IgG subclass deficiency.
• Wiskott-Aldrich syndrome.
• Ataxia telangiectasia.
• DiGeorge syndrome
• Hyper-IgE syndrome.
• X-linked lymphoproliferative syndrome.
• Chediak-Higashi syndrome.
• Bloom's syndrome.
• Enteropathy-associated T-cell lymphoma among northern Europeans.

Hashimoto's thyroiditis (for MALT lymphomas).

Non-Hodgkins Lymphoma - Reference:

1. J. Occup. Environ. Med2002 May; 44(5): 469-74
   "Occupation and risk of non-Hodgkin's lymphoma and chronic lymphocytic leukemia".
   Zheng T, Blair A, Zhang Y, Weisenburger DD, Zahm SH.

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